Small molecule, nanoparticle and liposomal strategies for LAT1-mediated chemotherapy delivery

Jeanee L. Bullock; Devyn D. Gillette; Jacqueline A. Smith

Results in Chemistry (Dec 2023)

Small molecule, nanoparticle and liposomal strategies for LAT1-mediated chemotherapy delivery

Jeanee L. Bullock,
Devyn D. Gillette,
Jacqueline A. Smith

Affiliations

Jeanee L. Bullock: Bowie State University, Department of Natural Sciences, 14000 Jericho Park Dr., Bowie, MD 20715, USA
Devyn D. Gillette: Bowie State University, Department of Natural Sciences, 14000 Jericho Park Dr., Bowie, MD 20715, USA
Jacqueline A. Smith: Corresponding author.; Bowie State University, Department of Natural Sciences, 14000 Jericho Park Dr., Bowie, MD 20715, USA

Journal volume & issue: Vol. 6
p. 101056

Abstract

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LAT1 has become a popular target for anti-cancer therapeutics due to its role as a nutrient transporter and abundant expression in cancer cells. Although small molecule inhibition has been the major focus of LAT1-based chemotherapies, using LAT1-substrates as a carrier will allow delivery of known drugs to cells, improving their intracellular uptake and thus decreasing concentrations required to give the desired biological effect. This review highlights the current efforts in using LAT1-amino acid substrates as carriers for chemotherapeutic delivery.

Published in Results in Chemistry

ISSN: 2211-7156 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: https://www.journals.elsevier.com/results-in-chemistry/

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