Nature Communications (Sep 2017)

A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol

  • Chia-Jung Chang,
  • Chien-Hsiun Chen,
  • Bing-Mae Chen,
  • Yu-Cheng Su,
  • Ying-Ting Chen,
  • Michael S. Hershfield,
  • Ming-Ta Michael Lee,
  • Tian-Lu Cheng,
  • Yuan-Tsong Chen,
  • Steve R. Roffler,
  • Jer-Yuarn Wu

DOI
https://doi.org/10.1038/s41467-017-00622-4
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 7

Abstract

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Some individuals develop antibodies against the polyethylene glycol that is commonly used in therapeutic preparations. Here the authors conduct a GWAS in Han Chinese and find the IGH locus is associated with anti-PEG IgM.