中国甲状腺功能正常人群对甲状腺激素的敏感性和代谢综合征组分的风险

Abstract

Abstract Introduction To evaluate the association of sensitivity to thyroid hormone with metabolic syndrome (MetS) and its components in a Chinese euthyroid population. Methods A total of 3573 participants from Pinggu Metabolic Disease Study were analyzed. Serum‐free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin (TSH), total adipose tissue (TAT), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) area of abdominal, and lumbar skeletal muscle area (SMA) were measured. Central thyroid hormone resistance was calculated by the Thyroid Feedback Quantile‐based Index (TFQI) and Chinese‐referenced Parametric TFQI (PTFQI), Thyrotroph T4 Resistance Index (TT4RI) and TSH Index (TSHI). Peripheral thyroid hormone resistance was assessed by FT3/FT4 ratio. Results Higher values of TSHI (odds ratio [OR] = 1.167, 95% confidence interval [CI]: 1.079–1.262, p < .001), TT4RI (OR = 1.115, 95% CI: 1.031–1.206, p = .006), TFQI (OR = 1.196, 95% CI: 1.106–1.294, p < .001), PTFQI (OR = 1.194, 95% CI: 1.104–1.292, p < .001), and lower values of FT3/FT4 ratio (OR = 0.914, 95% CI: 0.845–0.990, p = .026) were associated with MetS. Increased levels of TFQI and PTFQI were associated with abdominal obesity, hypertriglyceridemia, and hypertension. Increased levels of TSHI and TT4RI were associated with hypertriglyceridemia, abdominal obesity, low high‐density lipoprotein cholesterol. Reduced levels of FT3/FT4 ratio were associated with hyperglycemia, hypertension, and hypertriglyceridemia. The levels of TSHI, TFQI, and PTFQI were negatively related to SMA and positively related to VAT, SAT, and TAT (all p < .05). Conclusions Reduced thyroid hormone sensitivity was associated with MetS and its components. Impaired thyroid hormone sensitivity might affect the distribution of adipose tissue and muscle.

Keywords

• 甲状腺激素敏感性
• 代谢综合征
• 骨骼肌
• 脂肪组织