Nature Communications (Jul 2020)
Ethanol exposure increases mutation rate through error-prone polymerases
- Karin Voordeckers,
- Camilla Colding,
- Lavinia Grasso,
- Benjamin Pardo,
- Lore Hoes,
- Jacek Kominek,
- Kim Gielens,
- Kaat Dekoster,
- Jonathan Gordon,
- Elisa Van der Zande,
- Peter Bircham,
- Toon Swings,
- Jan Michiels,
- Peter Van Loo,
- Sandra Nuyts,
- Philippe Pasero,
- Michael Lisby,
- Kevin J. Verstrepen
Affiliations
- Karin Voordeckers
- Laboratory of Systems Biology, VIB-KU Leuven Center for Microbiology
- Camilla Colding
- Department of Biology, University of Copenhagen
- Lavinia Grasso
- Institut de Génétique Humaine, CNRS and Université de Montpellier, 141 rue de la Cardonille
- Benjamin Pardo
- Institut de Génétique Humaine, CNRS and Université de Montpellier, 141 rue de la Cardonille
- Lore Hoes
- Laboratory of Systems Biology, VIB-KU Leuven Center for Microbiology
- Jacek Kominek
- Laboratory of Systems Biology, VIB-KU Leuven Center for Microbiology
- Kim Gielens
- Laboratory of Systems Biology, VIB-KU Leuven Center for Microbiology
- Kaat Dekoster
- Laboratory of Systems Biology, VIB-KU Leuven Center for Microbiology
- Jonathan Gordon
- Laboratory of Systems Biology, VIB-KU Leuven Center for Microbiology
- Elisa Van der Zande
- Laboratory of Systems Biology, VIB-KU Leuven Center for Microbiology
- Peter Bircham
- Laboratory of Systems Biology, VIB-KU Leuven Center for Microbiology
- Toon Swings
- Centre of Microbial and Plant Genetics, KU Leuven
- Jan Michiels
- Centre of Microbial and Plant Genetics, KU Leuven
- Peter Van Loo
- The Francis Crick Institute
- Sandra Nuyts
- Laboratory of Experimental Radiotherapy, Department of Oncology, KU Leuven
- Philippe Pasero
- Institut de Génétique Humaine, CNRS and Université de Montpellier, 141 rue de la Cardonille
- Michael Lisby
- Department of Biology, University of Copenhagen
- Kevin J. Verstrepen
- Laboratory of Systems Biology, VIB-KU Leuven Center for Microbiology
- DOI
- https://doi.org/10.1038/s41467-020-17447-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Whereas the toxic effects of ethanol are well-documented, the underlying mechanism is obscure. This study uses the eukaryotic model S. cerevisiae to reveal how exposure to sublethal ethanol concentrations causes DNA replication stress and an increased mutation rate.
