Homeostatic plasticity shapes the visual system’s first synapse

Robert E. Johnson; Nai-Wen Tien; Ning Shen; James T. Pearson; Florentina Soto; Daniel Kerschensteiner

doi:10.1038/s41467-017-01332-7

Nature Communications (Oct 2017)

Homeostatic plasticity shapes the visual system’s first synapse

Robert E. Johnson,
Nai-Wen Tien,
Ning Shen,
James T. Pearson,
Florentina Soto,
Daniel Kerschensteiner

Affiliations

Robert E. Johnson: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine
Nai-Wen Tien: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine
Ning Shen: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine
James T. Pearson: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine
Florentina Soto: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine
Daniel Kerschensteiner: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-017-01332-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Retinal rod bipolar cells (RBCs) partially undergo programmed cell death triggering cell density-dependent plasticity. This study shows that increased removal of RBCs using genetic approaches causes dendrites of the remaining RBCs to expand and contact more rod photoreceptors while reducing connectivity with each.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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