Spontaneously evolved progenitor niches escape Yap oncogene addiction in advanced pancreatic ductal adenocarcinomas

Shigekazu Murakami; Shannon M. White; Alec T. McIntosh; Chan D. K. Nguyen; Chunling Yi

doi:10.1038/s41467-023-37147-y

Nature Communications (Mar 2023)

Spontaneously evolved progenitor niches escape Yap oncogene addiction in advanced pancreatic ductal adenocarcinomas

Shigekazu Murakami,
Shannon M. White,
Alec T. McIntosh,
Chan D. K. Nguyen,
Chunling Yi

Affiliations

Shigekazu Murakami: Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
Shannon M. White: Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
Alec T. McIntosh: Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
Chan D. K. Nguyen: Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
Chunling Yi: Lombardi Comprehensive Cancer Center, Georgetown University Medical Center

DOI: https://doi.org/10.1038/s41467-023-37147-y
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 20

Abstract

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It remains unclear how spontaneous Pancreatic Ductal Adenocarcinoma (PDAC) tumors escape Yap dependency. Here, the authors show that lineage plasticity promotes spontaneous relapse following YAP ablation and reveal key transcriptional drivers that overcome YAP addiction in PDAC.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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