Developing a multifunctional gradient pore structure Janus membrane loaded with MB@ZIF-8 nanoparticles and hydroxyapatite for guided periodontal bone regeneration

Lijie Wang; Li Wan; Jianxin Wu; Yeke Chen; Yuting Yang; Tian Deng; JingTing Wu; Weiwei Xue; Li Song; Fang Dai

Materials & Design (Aug 2024)

Developing a multifunctional gradient pore structure Janus membrane loaded with MB@ZIF-8 nanoparticles and hydroxyapatite for guided periodontal bone regeneration

Lijie Wang,
Li Wan,
Jianxin Wu,
Yeke Chen,
Yuting Yang,
Tian Deng,
JingTing Wu,
Weiwei Xue,
Li Song,
Fang Dai

Affiliations

Lijie Wang: Center of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 33006, China; JXHC Key Laboratory of Periodontology (The Second Affiliated Hospital of Nanchang University),Nanchang 33006, China; The Institute of Periodontal Disease, Nanchang University, Nanchang 33006, China; The Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi 33006, China
Li Wan: School of Advanced Manufacturing, Nanchang University, Nanchang, Jiangxi 33006, China
Jianxin Wu: Center of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 33006, China; JXHC Key Laboratory of Periodontology (The Second Affiliated Hospital of Nanchang University),Nanchang 33006, China; The Institute of Periodontal Disease, Nanchang University, Nanchang 33006, China; The Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi 33006, China
Yeke Chen: Center of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 33006, China; JXHC Key Laboratory of Periodontology (The Second Affiliated Hospital of Nanchang University),Nanchang 33006, China; The Institute of Periodontal Disease, Nanchang University, Nanchang 33006, China; The Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi 33006, China
Yuting Yang: Center of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 33006, China; JXHC Key Laboratory of Periodontology (The Second Affiliated Hospital of Nanchang University),Nanchang 33006, China; The Institute of Periodontal Disease, Nanchang University, Nanchang 33006, China; The Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi 33006, China
Tian Deng: Center of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 33006, China; JXHC Key Laboratory of Periodontology (The Second Affiliated Hospital of Nanchang University),Nanchang 33006, China; The Institute of Periodontal Disease, Nanchang University, Nanchang 33006, China
JingTing Wu: Center of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 33006, China; JXHC Key Laboratory of Periodontology (The Second Affiliated Hospital of Nanchang University),Nanchang 33006, China; The Institute of Periodontal Disease, Nanchang University, Nanchang 33006, China
Weiwei Xue: Center of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 33006, China; JXHC Key Laboratory of Periodontology (The Second Affiliated Hospital of Nanchang University),Nanchang 33006, China; The Institute of Periodontal Disease, Nanchang University, Nanchang 33006, China
Li Song: Center of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 33006, China; JXHC Key Laboratory of Periodontology (The Second Affiliated Hospital of Nanchang University),Nanchang 33006, China; The Institute of Periodontal Disease, Nanchang University, Nanchang 33006, China; Corresponding authors at: Center of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 33006, China.
Fang Dai: Center of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 33006, China; JXHC Key Laboratory of Periodontology (The Second Affiliated Hospital of Nanchang University),Nanchang 33006, China; The Institute of Periodontal Disease, Nanchang University, Nanchang 33006, China; Corresponding authors at: Center of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 33006, China.

Journal volume & issue: Vol. 244
p. 113126

Abstract

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The guided tissue regeneration (GTR) procedure has become an important process for the treatment of periodontal tissue regeneration, using the membrane as a mechanical barrier to generate a distance across the defect that subsequently allowing bone regeneration. Due to the complexity of periodontal microenvironment caused by bacterial infections, inflammation, and fibrous tissue penetration, the guided tissue regeneration membrane is required to have antibacterial and barrier functions. We developed a loaded methylene blue @ ZIF-8 and hydroxyapatite gradient thermoplastic polyurethane Janus membrane for antibacterial osteogenic and barrier. This Janus membrane with a porous gradient structure was prepared to use phase-conversion method. The rough layer facilitated cell growth and promoted periodontal bone regeneration, whereas the smooth layer isolated the growing fiber tissue.The rapid release of reactive oxygen species in the early stage and continuous release of zinc ions by methylene blue @ZIF-8 can achieve long-term synergistic antibacterial effect, with antibacterial rates of 84 % and 72 % against Escherichia coli and Staphylococcus aureus, respectively, which can effectively reduce the local inflammation caused by bacteria. In summary, we applied the Janus membrane to a rat periodontal bone defect model, and the membrane showed good surgical performance, barrier properties, osteogenic properties, and antibacterial effects, which could have broad application prospects in the treatment of periodontal bone defects.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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