Cell Death and Disease (Dec 2020)
Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors
- Alessandro Alaimo,
- Marco Lorenzoni,
- Paolo Ambrosino,
- Arianna Bertossi,
- Alessandra Bisio,
- Alice Macchia,
- Eugenio Zoni,
- Sacha Genovesi,
- Francesco Cambuli,
- Veronica Foletto,
- Dario De Felice,
- Maria Virginia Soldovieri,
- Ilaria Mosca,
- Francesco Gandolfi,
- Matteo Brunelli,
- Gianluca Petris,
- Anna Cereseto,
- Alvaro Villarroel,
- George Thalmann,
- Francesco Giuseppe Carbone,
- Marianna Kruithof-de Julio,
- Mattia Barbareschi,
- Alessandro Romanel,
- Maurizio Taglialatela,
- Andrea Lunardi
Affiliations
- Alessandro Alaimo
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Marco Lorenzoni
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Paolo Ambrosino
- Department of Science and Technology (DST), University of Sannio
- Arianna Bertossi
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Alessandra Bisio
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Alice Macchia
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Eugenio Zoni
- Department for BioMedical Research, Urology Research Laboratory, University of Bern
- Sacha Genovesi
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Francesco Cambuli
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Veronica Foletto
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Dario De Felice
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Maria Virginia Soldovieri
- Department of Medicine and Health Sciences, University of Molise
- Ilaria Mosca
- Department of Medicine and Health Sciences, University of Molise
- Francesco Gandolfi
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Matteo Brunelli
- Department of Pathology AOUI, University of Verona
- Gianluca Petris
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Anna Cereseto
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Alvaro Villarroel
- Biofisika Institute (CSIC, UPV/EHU), University of the Basque Country
- George Thalmann
- Department for BioMedical Research, Urology Research Laboratory, University of Bern
- Francesco Giuseppe Carbone
- Unit of Surgical Pathology, Santa Chiara Hospital
- Marianna Kruithof-de Julio
- Department for BioMedical Research, Urology Research Laboratory, University of Bern
- Mattia Barbareschi
- Unit of Surgical Pathology, Santa Chiara Hospital
- Alessandro Romanel
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Maurizio Taglialatela
- Department of Neuroscience, University of Naples “Federico II”
- Andrea Lunardi
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- DOI
- https://doi.org/10.1038/s41419-020-03256-5
- Journal volume & issue
-
Vol. 11,
no. 12
pp. 1 – 17
Abstract
Abstract Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms to lethal conditions, thus offering new therapeutic avenues for cancer treatment. Here, we demonstrate that selective agonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), a cation channel characteristic of the prostate epithelium frequently overexpressed in advanced stage III/IV prostate cancers (PCa), sensitize therapy refractory models of PCa to radio, chemo or hormonal treatment. Overall, our study demonstrates that pharmacological-induced Ca2+ cytotoxicity is an actionable strategy to sensitize cancer cells to standard therapies.
