STUDYING PSYCHOIMMUNOMODULATING EFFECT OF SUCCINATE PHENOTROPIL IN EXPERIMENTAL MODEL

Abstract

Аbstract. Psychoimmunomodulating properties of phenotropil succinate, a new phenotropil derivative, were studied in a model of cyclophosphamide-induced immunodepression and lypopolysaccharideinduced immune stress, following intraperitoneal injections of the drug at different schedules (from a single injection up to a 7-day course), and at varying doses (25 mg/kg, 50 mg/kg, and 100 mg/kg). It was found that the studied substance shows a clear ability to eliminate disorders of various immune compartments. Moreover, phenotropil succinate was able to restore behavioral reactions in “Suоk-test”. These results provide evidence for development of this substance aimed for correction of neuroimmune disturbances. (Med. Immunol., 2011, vol. 13, N 1, pp 55-60)

Keywords

• succinate phenotropil
• neuroimmune correction
• “immune” stress
• immunodepression
• cyclophosphamide
• lypopolysaccharide
• in vivo model