ATTRITION OF A DESIRED PREGNANCY, IN A 37-YEAR-OLD WOMAN WITH TROMBOPHILIA WITH 2 PREVIOUS MISCARRIAGES

Abstract

Thrombophilias are inherited or acquired conditions that predispose individuals to thromboembolism. Thrombophilic disorders increase obstetric complications, such as early pregnancy loss, fetal growth retardation, placental abruption, and preeclampsia. Recurrent pregnancy loss affects 1% to 3% of women of reproductive age, and a large proportion of these losses remain unexplained. Genetic thrombophilia is the cause of approximately 49% -- 65% of the complications during pregnancy(1). This article presents a clinical case study of a patient who has experienced two previous unsuccessful pregnancies, who is proven to be a heterozygote via mutant allele of MTHFR (Ala222Val) and PAI-1 (4G/5G), with heightened levels of NK cells with increased cell activity, and evidence of inhibiting embryotoxin in a blood test performed via DNA isolation, and DNA analysis via real time PCR.

Keywords

• pregnancy
• gestation
• pai-1
• mutant allele mthfr
• thrombophilia
• nk cells