Hepatotoxicity of new oral anticoagulants: literature review

Abstract

Tis article presents a literature review of hepatotoxicity of new oral anticoagulants which was obtained by different methods options of pharmacovigilance. Te overview includes 35 information sources 24 articles, 4 methodic or regulatory guidelines, 3 expert group publications, 3 new drug application overviews and 1 source being clinical trial register search results. Upon the results of the literature review, it was concluded that pharmacovigilance methods analyzing data obtained within real world medical practice give more opportunities for safety signal management comparing to those analyzing only data obtained within randomized clinical trials.

Keywords

• новые оральные антикоагулянты
• повреждение печени
• фармаконадзор
• сигналы по безопасности
• литературный обзор