A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions

Changhao Wang; Qianqian Qi; Wenying Li; Jingshuang Dang; Min Hao; Shuting Lv; Xingchen Dong; Youkun Gu; Peizhe Wu; Wenyue Zhang; Yashao Chen; Jörg S. Hartig

doi:10.1038/s41467-020-18554-x

Nature Communications (Sep 2020)

A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions

Changhao Wang,
Qianqian Qi,
Wenying Li,
Jingshuang Dang,
Min Hao,
Shuting Lv,
Xingchen Dong,
Youkun Gu,
Peizhe Wu,
Wenyue Zhang,
Yashao Chen,
Jörg S. Hartig

Affiliations

Changhao Wang: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University
Qianqian Qi: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University
Wenying Li: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University
Jingshuang Dang: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University
Min Hao: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University
Shuting Lv: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University
Xingchen Dong: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University
Youkun Gu: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University
Peizhe Wu: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University
Wenyue Zhang: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University
Yashao Chen: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University
Jörg S. Hartig: Department of Chemistry and Konstanz Research School Chemical Biology (KoRS-CB), University of Konstanz

DOI: https://doi.org/10.1038/s41467-020-18554-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 8

Abstract

Read online

ATP acts as a co-substrate in enzyme catalysed reactions, but can also specifically bind metal ions. Here, the authors show that ATP interacts with copper ions and forms a Cu(II)-ATP complex that efficiently catalyses Diels-Alder reactions, and determine ATP residues that are essential for this activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal