Frontiers in Medicine (Apr 2022)
Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol
- Giovanni Berardi,
- Laura Frey-Law,
- Kathleen A. Sluka,
- Emine O. Bayman,
- Christopher S. Coffey,
- Dixie Ecklund,
- Carol G. T. Vance,
- Dana L. Dailey,
- John Burns,
- Asokumar Buvanendran,
- Robert J. McCarthy,
- Joshua Jacobs,
- Xiaohong Joe Zhou,
- Richard Wixson,
- Tessa Balach,
- Chad M. Brummett,
- Daniel Clauw,
- Daniel Clauw,
- Daniel Clauw,
- Douglas Colquhoun,
- Steven E. Harte,
- Steven E. Harte,
- Richard E. Harris,
- Richard E. Harris,
- David A. Williams,
- David A. Williams,
- David A. Williams,
- David A. Williams,
- Andrew C. Chang,
- Jennifer Waljee,
- Kathleen M. Fisch,
- Kristen Jepsen,
- Louise C. Laurent,
- Michael Olivier,
- Carl D. Langefeld,
- Timothy D. Howard,
- Oliver Fiehn,
- Jon M. Jacobs,
- Panshak Dakup,
- Wei-Jun Qian,
- Adam C. Swensen,
- Anna Lokshin,
- Martin Lindquist,
- Brian S. Caffo,
- Ciprian Crainiceanu,
- Scott Zeger,
- Ari Kahn,
- Tor Wager,
- Margaret Taub,
- James Ford,
- Stephani P. Sutherland,
- Laura D. Wandner
Affiliations
- Giovanni Berardi
- Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Laura Frey-Law
- Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Kathleen A. Sluka
- Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Emine O. Bayman
- Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, United States
- Christopher S. Coffey
- Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, United States
- Dixie Ecklund
- Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, United States
- Carol G. T. Vance
- Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Dana L. Dailey
- Department of Physical Therapy, St. Ambrose University, Davenport, IA, United States
- John Burns
- Department of Psychiatry, Rush University Medical Center, Chicago, IL, United States
- Asokumar Buvanendran
- Department of Anesthesiology, Rush University Medical Center, Chicago, IL, United States
- Robert J. McCarthy
- Department of Anesthesiology, Rush University Medical Center, Chicago, IL, United States
- Joshua Jacobs
- Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, United States
- Xiaohong Joe Zhou
- Departments of Radiology, Neurosurgery, and Bioengineering, University of Illinois College of Medicine at Chicago, Chicago, IL, United States
- Richard Wixson
- NorthShore Orthopaedic and Spine Institute, NorthShore University HealthSystem, Skokie, IL, United States
- Tessa Balach
- Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago, Chicago, IL, United States
- Chad M. Brummett
- 0Department of Anesthesiology, University of Michigan, Ann Arbor, MI, United States
- Daniel Clauw
- 0Department of Anesthesiology, University of Michigan, Ann Arbor, MI, United States
- Daniel Clauw
- 1Department of Medicine (Rheumatology), University of Michigan, Ann Arbor, MI, United States
- Daniel Clauw
- 2Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States
- Douglas Colquhoun
- 0Department of Anesthesiology, University of Michigan, Ann Arbor, MI, United States
- Steven E. Harte
- 0Department of Anesthesiology, University of Michigan, Ann Arbor, MI, United States
- Steven E. Harte
- 1Department of Medicine (Rheumatology), University of Michigan, Ann Arbor, MI, United States
- Richard E. Harris
- 0Department of Anesthesiology, University of Michigan, Ann Arbor, MI, United States
- Richard E. Harris
- 1Department of Medicine (Rheumatology), University of Michigan, Ann Arbor, MI, United States
- David A. Williams
- 0Department of Anesthesiology, University of Michigan, Ann Arbor, MI, United States
- David A. Williams
- 1Department of Medicine (Rheumatology), University of Michigan, Ann Arbor, MI, United States
- David A. Williams
- 2Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States
- David A. Williams
- 3Department of Psychology, University of Michigan, Ann Arbor, MI, United States
- Andrew C. Chang
- 4Section of Thoracic Surgery, University of Michigan, Ann Arbor, MI, United States
- Jennifer Waljee
- 5Section of Plastic and Reconstructive Surgery, University of Michigan, Ann Arbor, MI, United States
- Kathleen M. Fisch
- 6Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Diego, La Jolla, CA, United States
- Kristen Jepsen
- 7Institute of Genomic Medicine Genomics Center, University of California, San Diego, La Jolla, CA, United States
- Louise C. Laurent
- 6Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Diego, La Jolla, CA, United States
- Michael Olivier
- 8Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States
- Carl D. Langefeld
- 9Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, United States
- Timothy D. Howard
- 0Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, United States
- Oliver Fiehn
- 1West Coast Metabolomics Center, University of California, Davis, Davis, CA, United States
- Jon M. Jacobs
- 2Environmental and Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, United States
- Panshak Dakup
- 2Environmental and Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, United States
- Wei-Jun Qian
- 2Environmental and Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, United States
- Adam C. Swensen
- 2Environmental and Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, United States
- Anna Lokshin
- 3Department of Pathology, University of Pittsburgh, Pittsburgh, PA, United States
- Martin Lindquist
- 4Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
- Brian S. Caffo
- 4Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
- Ciprian Crainiceanu
- 4Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
- Scott Zeger
- 4Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
- Ari Kahn
- 5Texas Advanced Computing Center, The University of Texas at Austin, Austin, TX, United States
- Tor Wager
- 6Presidential Cluster in Neuroscience, Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, United States
- Margaret Taub
- 4Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
- James Ford
- 7Geisel School of Medicine at Dartmouth, Hanover, NH, United States
- Stephani P. Sutherland
- 4Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
- Laura D. Wandner
- 8National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, MD, United States
- DOI
- https://doi.org/10.3389/fmed.2022.849214
- Journal volume & issue
-
Vol. 9
Abstract
Chronic pain has become a global health problem contributing to years lived with disability and reduced quality of life. Advances in the clinical management of chronic pain have been limited due to incomplete understanding of the multiple risk factors and molecular mechanisms that contribute to the development of chronic pain. The Acute to Chronic Pain Signatures (A2CPS) Program aims to characterize the predictive nature of biomarkers (brain imaging, high-throughput molecular screening techniques, or “omics,” quantitative sensory testing, patient-reported outcome assessments and functional assessments) to identify individuals who will develop chronic pain following surgical intervention. The A2CPS is a multisite observational study investigating biomarkers and collective biosignatures (a combination of several individual biomarkers) that predict susceptibility or resilience to the development of chronic pain following knee arthroplasty and thoracic surgery. This manuscript provides an overview of data collection methods and procedures designed to standardize data collection across multiple clinical sites and institutions. Pain-related biomarkers are evaluated before surgery and up to 3 months after surgery for use as predictors of patient reported outcomes 6 months after surgery. The dataset from this prospective observational study will be available for researchers internal and external to the A2CPS Consortium to advance understanding of the transition from acute to chronic postsurgical pain.
Keywords
