Nature Communications (Sep 2020)

IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration

  • Rania Dagher,
  • Alan M. Copenhaver,
  • Valerie Besnard,
  • Aaron Berlin,
  • Fatima Hamidi,
  • Marielle Maret,
  • Jingya Wang,
  • Xiaotao Qu,
  • Yashaswi Shrestha,
  • Jincheng Wu,
  • Gregory Gautier,
  • Rajiv Raja,
  • Michel Aubier,
  • Roland Kolbeck,
  • Alison A. Humbles,
  • Marina Pretolani

DOI
https://doi.org/10.1038/s41467-020-18466-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 19

Abstract

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Signaling of IL-33 via its receptor, ST2, has been implicated in macrophage function in tissue repair. Here the authors show, using genetic mouse models and single-cell transcriptomic data, that the IL-33/ST2 axis regulates both ILC2-derived IL-13 and macrophage differentiation/reparative function required for club cell regeneration.