BMJ Open (May 2023)
ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK
- Gavin Giovannoni,
- Eli Silber,
- Ruth Dobson,
- Riffat Tanveer,
- Jade Harris,
- Tarunya Arun,
- Miriam Mattoscio,
- Ghaniah Hassan-Smith,
- Huw Morris,
- Rod Middleton,
- Emma Tallantyre,
- David Rog,
- Nikos Evangelou,
- Benjamin M Jacobs,
- Antonio Scalfari,
- Waqar Rashid,
- Helen L Ford,
- Charles A Mein,
- Stephen Sawcer,
- Cord Spilker,
- Bruno Gran,
- Martin O'Malley,
- Ashwini Nandoskar,
- Emeka Uzochukwu,
- Katila George,
- Sadid Hoque,
- Luisa Schalk,
- Angie Dunne,
- Charlotte Sellers,
- Elisa Visentin,
- Elizabeth Lindsey Bezzina,
- Eva Wozniak,
- Eve Sacre,
- Joan Bradley,
- Joshua Breedon,
- Judith Brooke,
- Karim L Kreft,
- Katherine Tuite Dalton,
- Maria Papachatzaki,
- Michelle Peter,
- Neisha Rhule,
- Nimisha Vinod,
- Outi Quinn,
- Ramya Shamji,
- Rashmi Kaimal,
- Rebecca Boulton,
- Roxanne Murray,
- Ruth Bellfield,
- Shakeelah Patel,
- Sonia Raj,
- Stephanie Gumus,
- Stephanie Mitchell,
- Tatiana Pogreban,
- Terri-Louise Brown,
- Thamanna Begum,
- Veronica Antoine
Affiliations
- Gavin Giovannoni
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
- Eli Silber
- Kings College Hospital and Lewisham and Greenwich NHS Trusts, London, UK
- Ruth Dobson
- Royal London Hospital, Barts Health NHS Trust, London, UK
- Riffat Tanveer
- Lancashire Teaching Hospital NHS Foundation Trust, Preston, UK
- Jade Harris
- Northern Care Alliance NHS Trust, Manchester, UK
- Tarunya Arun
- University Hospitals of Coventry and Warwickshire, Coventry, UK
- Miriam Mattoscio
- Department of neuroscience, Queen`s Hospital, BHRUT NHS Trust, Romford, UK
- Ghaniah Hassan-Smith
- University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
- Huw Morris
- Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, London, UK
- Rod Middleton
- Population Data Science, Swansea University Medical School, Swansea, UK
- Emma Tallantyre
- Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK
- David Rog
- Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Trust, Manchester, UK
- Nikos Evangelou
- Department of Neurology, Nottingham University Hospitals NHS Trust; Mental Health and Clinical Neuroscience Academic Unit, University of Nottingham School of Medicine, Nottingham, UK
- Benjamin M Jacobs
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
- Antonio Scalfari
- Centre of Neuroscience, Department of Medicine, Imperial College London, London, UK
- Waqar Rashid
- St George`s University Hospitals NHS Foundation Trust, London, UK
- Helen L Ford
- Leeds Centre for Neurosciences, Leeds teaching Hospitals NHS Trust, Leeds, UK
- Charles A Mein
- Barts and the London Genome Centre, Queen Mary University of London, London, UK
- Stephen Sawcer
- University of Cambridge, Department of Clinical Neuroscience, Addenbrookes Hospital, Hills Road, Cambridge, UK
- Cord Spilker
- Bradford Teaching Hospital Foundation Trust, Bradford, UK
- Bruno Gran
- Department of Neurology, Nottingham University Hospitals NHS Trust, Mental Health and Clinical Neuroscience Academic Unit, University of Nottingham School of Medicine, Nottingham, UK
- Martin O'Malley
- Leeds Centre for Neurosciences, Leeds teaching Hospitals NHS Trust, Leeds, UK
- Ashwini Nandoskar
- Hillingdon and Imperial NHS Trust, London, UK
- Emeka Uzochukwu
- Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK
- Katila George
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
- Sadid Hoque
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
- Luisa Schalk
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
- Angie Dunne
- Leeds Centre for Neurosciences, Leeds teaching Hospitals NHS Trust, Leeds, UK
- Charlotte Sellers
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
- Elisa Visentin
- Research and Innovation, Queen`s Hospital, BHRUT, London, UK
- Elizabeth Lindsey Bezzina
- Kings College Hospital and Lewisham and Greenwich NHS Trusts, London, UK
- Eva Wozniak
- Barts and the London Genome Centre, Queen Mary University of London, London, UK
- Eve Sacre
- Leeds Centre for Neurosciences, Leeds teaching Hospitals NHS Trust, Leeds, UK
- Joan Bradley
- Hillingdon and Imperial NHS Trust, Uxbridge, UK
- Joshua Breedon
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
- Judith Brooke
- Northern Care Alliance NHS Trust, Manchester, UK
- Karim L Kreft
- Department of Neurology, University Hospital of Wales, Cardiff, UK
- Katherine Tuite Dalton
- Population Data Science, Swansea University Medical School, Swansea, UK
- Maria Papachatzaki
- Mid and South Essex NHS Foundation Trust, Southend-on-Sea, UK
- Michelle Peter
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
- Neisha Rhule
- Queen Elizabeth Hospital (Lewisham and Greenwich NHS Trust), London, UK
- Nimisha Vinod
- Northern Care Alliance NHS Trust, Manchester, UK
- Outi Quinn
- Bradford Teaching Hospital Foundation Trust, Bradford, UK
- Ramya Shamji
- Research and Innovation, Queen`s Hospital, BHRUT, London, UK
- Rashmi Kaimal
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
- Rebecca Boulton
- Department of Neurology, Nottingham University Hospitals NHS Trust; Mental Health and Clinical Neuroscience Academic Unit, University of Nottingham School of Medicine, Nottingham, UK
- Roxanne Murray
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
- Ruth Bellfield
- Bradford Teaching Hospital Foundation Trust, Bradford, UK
- Shakeelah Patel
- Lancashire Teaching Hospital NHS Foundation Trust, Preston, UK
- Sonia Raj
- Lancashire Teaching Hospital NHS Foundation Trust, Preston, UK
- Stephanie Gumus
- Mid and South Essex NHS Foundation Trust, Southend-on-Sea, UK
- Stephanie Mitchell
- Northern Care Alliance NHS Trust, Manchester, UK
- Tatiana Pogreban
- Research and Innovation, Queen`s Hospital, BHRUT, London, UK
- Terri-Louise Brown
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
- Thamanna Begum
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
- Veronica Antoine
- Northern Care Alliance NHS Trust, Manchester, UK
- DOI
- https://doi.org/10.1136/bmjopen-2023-071656
- Journal volume & issue
-
Vol. 13,
no. 5
Abstract
Purpose Genetic studies of multiple sclerosis (MS) susceptibility and severity have focused on populations of European ancestry. Studying MS genetics in other ancestral groups is necessary to determine the generalisability of these findings. The genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis (ADAMS) project aims to gather genetic and phenotypic data on a large cohort of ancestrally-diverse individuals with MS living in the UK.Participants Adults with self-reported MS from diverse ancestral backgrounds. Recruitment is via clinical sites, online (https://app.mantal.co.uk/adams) or the UK MS Register. We are collecting demographic and phenotypic data using a baseline questionnaire and subsequent healthcare record linkage. We are collecting DNA from participants using saliva kits (Oragene-600) and genotyping using the Illumina Global Screening Array V.3.Findings to date As of 3 January 2023, we have recruited 682 participants (n=446 online, n=55 via sites, n=181 via the UK MS Register). Of this initial cohort, 71.2% of participants are female, with a median age of 44.9 years at recruitment. Over 60% of the cohort are non-white British, with 23.5% identifying as Asian or Asian British, 16.2% as Black, African, Caribbean or Black British and 20.9% identifying as having mixed or other backgrounds. The median age at first symptom is 28 years, and median age at diagnosis is 32 years. 76.8% have relapsing–remitting MS, and 13.5% have secondary progressive MS.Future plans Recruitment will continue over the next 10 years. Genotyping and genetic data quality control are ongoing. Within the next 3 years, we aim to perform initial genetic analyses of susceptibility and severity with a view to replicating the findings from European-ancestry studies. In the long term, genetic data will be combined with other datasets to further cross-ancestry genetic discoveries.
