Nature Communications (Feb 2022)
Tracking cryptic SARS-CoV-2 lineages detected in NYC wastewater
- Davida S. Smyth,
- Monica Trujillo,
- Devon A. Gregory,
- Kristen Cheung,
- Anna Gao,
- Maddie Graham,
- Yue Guan,
- Caitlyn Guldenpfennig,
- Irene Hoxie,
- Sherin Kannoly,
- Nanami Kubota,
- Terri D. Lyddon,
- Michelle Markman,
- Clayton Rushford,
- Kaung Myat San,
- Geena Sompanya,
- Fabrizio Spagnolo,
- Reinier Suarez,
- Emma Teixeiro,
- Mark Daniels,
- Marc C. Johnson,
- John J. Dennehy
Affiliations
- Davida S. Smyth
- Department of Life Sciences, Texas A&M University-San Antonio
- Monica Trujillo
- Department of Biological Sciences and Geology, Queensborough Community College of The City University of New York
- Devon A. Gregory
- Department of Molecular Microbiology and Immunology, University of Missouri-School of Medicine
- Kristen Cheung
- Biology Department, Queens College and The Graduate Center of The City University of New York
- Anna Gao
- Biology Department, Queens College and The Graduate Center of The City University of New York
- Maddie Graham
- Department of Molecular Microbiology and Immunology, University of Missouri-School of Medicine
- Yue Guan
- Department of Molecular Microbiology and Immunology, University of Missouri-School of Medicine
- Caitlyn Guldenpfennig
- Department of Molecular Microbiology and Immunology, University of Missouri-School of Medicine
- Irene Hoxie
- Biology Department, Queens College and The Graduate Center of The City University of New York
- Sherin Kannoly
- Biology Department, Queens College and The Graduate Center of The City University of New York
- Nanami Kubota
- Biology Department, Queens College and The Graduate Center of The City University of New York
- Terri D. Lyddon
- Department of Molecular Microbiology and Immunology, University of Missouri-School of Medicine
- Michelle Markman
- Biology Department, Queens College and The Graduate Center of The City University of New York
- Clayton Rushford
- Department of Molecular Microbiology and Immunology, University of Missouri-School of Medicine
- Kaung Myat San
- Biology Department, Queens College and The Graduate Center of The City University of New York
- Geena Sompanya
- Department of Life Sciences, Texas A&M University-San Antonio
- Fabrizio Spagnolo
- Department of Biological & Environmental Sciences, Long Island University–Post, Greenvale
- Reinier Suarez
- Department of Molecular Microbiology and Immunology, University of Missouri-School of Medicine
- Emma Teixeiro
- Department of Molecular Microbiology and Immunology, University of Missouri-School of Medicine
- Mark Daniels
- Department of Molecular Microbiology and Immunology, University of Missouri-School of Medicine
- Marc C. Johnson
- Department of Molecular Microbiology and Immunology, University of Missouri-School of Medicine
- John J. Dennehy
- Biology Department, Queens College and The Graduate Center of The City University of New York
- DOI
- https://doi.org/10.1038/s41467-022-28246-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 9
Abstract
To monitor the presence of novel SARS-CoV-2 variants in New York City, Smyth et al. perform deep-sequencing of the receptor binding domain of S protein in wastewater samples and find novel cryptic lineages containing mutations affecting ACE2-tropism and showing decreased neutralization by antibodies.
