Synthesis of orotic acid derivatives and their effects on stem cell proliferation

Abstract

Orotic acid esters and several N-arylhydrazones derivatives were synthesized and evaluated for their stem cell proliferation potential with human stromal stem cells (hMSCs) which was never studied before. Some of the derivatives exhibit convincing upregulation of proliferation which is believed to be due to substitution on the aromatic ring.

Keywords

• orotic hydrazide
• arylhydrazone
• mesenchymal stem cells
• proliferation