Revista da Sociedade Brasileira de Medicina Tropical (Oct 2022)

Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence

  • Maria da Penha Gomes Gouvea,
  • Isac Ribeiro Moulaz,
  • Thayná Martins Gouveia,
  • Karen Evelin Monlevade Lança,
  • Bárbara Sthefany de Paula Lacerda,
  • Beatriz Paoli Thompson,
  • Jéssica Polese,
  • Marina Deorce de Lima,
  • Rodrigo Ribeiro-Rodrigues,
  • José Geraldo Mill,
  • Valéria Valim

DOI
https://doi.org/10.1590/0037-8682-0106-2022
Journal volume & issue
Vol. 55

Abstract

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ABSTRACT Background: This study aimed to evaluate IgG and IgM levels in COVID-19 recurrence. Methods: The serum antibody levels and clinical data from 73 healthcare workers with SARS-CoV-2 divided into seroconverted (n=51) and non-seroconverted (n=22) groups were assessed. The presence of specific anti-nucleocapsid (anti-N) IgM and IgG for SARS-CoV-2 was evaluated. IgG antibodies to the SARS-CoV-2 spike receptor-binding domain were used to confirm non-seroconversion in all negative anti-N. Results: Four recurrent cases displayed mild symptoms and were non-seroconverted until the recurrence of symptoms. Conclusions: Undetectable anti-nucleocapsid IgM and IgG levels may be correlated with symptomatic COVID-19 recurrence.

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