Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

Awani Upadhyay; Aditya Pisupati; Timothy Jegla; Matt Crook; Keith J. Mickolajczyk; Matthew Shorey; Laura E. Rohan; Katherine A. Billings; Melissa M. Rolls; William O. Hancock; Wendy Hanna-Rose

doi:10.1038/ncomms13135

Nature Communications (Oct 2016)

Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

Awani Upadhyay,
Aditya Pisupati,
Timothy Jegla,
Matt Crook,
Keith J. Mickolajczyk,
Matthew Shorey,
Laura E. Rohan,
Katherine A. Billings,
Melissa M. Rolls,
William O. Hancock,
Wendy Hanna-Rose

Affiliations

Awani Upadhyay: Department of Biochemistry and Molecular Biology, The Pennsylvania State University
Aditya Pisupati: Department of Biology, The Pennsylvania State University
Timothy Jegla: Department of Biology, The Pennsylvania State University
Matt Crook: Department of Biochemistry and Molecular Biology, The Pennsylvania State University
Keith J. Mickolajczyk: Department of Biomedical Engineering, The Pennsylvania State University
Matthew Shorey: Department of Biochemistry and Molecular Biology, The Pennsylvania State University
Laura E. Rohan: Department of Biochemistry and Molecular Biology, The Pennsylvania State University
Katherine A. Billings: Department of Biology, The Pennsylvania State University
Melissa M. Rolls: Department of Biochemistry and Molecular Biology, The Pennsylvania State University
William O. Hancock: Department of Biomedical Engineering, The Pennsylvania State University
Wendy Hanna-Rose: Department of Biochemistry and Molecular Biology, The Pennsylvania State University

DOI: https://doi.org/10.1038/ncomms13135
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC. elegans and Drosophila, unveiling a metabolic-based regulation for TRPV channel activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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