Clostridium difficile infection in patients with chronic hepatic disease

Abstract

Clostridium difficile infection (CDI) associates in the spectrum of comorbidities, more and more often, chronic toxic metabolic or viral hepatic diseases. Patients with chronic hepatic diseases have more severe episodes of CDI with poorer prognosis than episodes of CDI that have occurred in patients with other comorbidities. The measures of prophylaxis and treatment of CDI in these patients require particularizations according to the risk factors and the clinical-evolutionary specificity of these patients. The present study aims to identify the main risk factors of these patients for CDI, as well as to evaluate the severity of the episodes of CDI, the rate of recurrence and death in these patients, compared to those without liver disease.

Keywords

• clostridium difficile
• chronic liver disease
• prophylaxis
• prognosis