The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer

Ghazal Mohseni; Ghazal Mohseni; Juan Li; Abakundana Nsenga Ariston Gabriel; Abakundana Nsenga Ariston Gabriel; Lutao Du; Yun-shan Wang; Chuanxin Wang

doi:10.3389/fimmu.2021.781032

Frontiers in Immunology (Nov 2021)

The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer

Ghazal Mohseni,
Ghazal Mohseni,
Juan Li,
Abakundana Nsenga Ariston Gabriel,
Abakundana Nsenga Ariston Gabriel,
Lutao Du,
Yun-shan Wang,
Chuanxin Wang

Affiliations

Ghazal Mohseni: Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
Ghazal Mohseni: Department of Clinical Laboratory Diagnostics, School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China
Juan Li: Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
Abakundana Nsenga Ariston Gabriel: Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
Abakundana Nsenga Ariston Gabriel: Department of Clinical Laboratory Diagnostics, School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China
Lutao Du: Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
Yun-shan Wang: Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
Chuanxin Wang: Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China

DOI: https://doi.org/10.3389/fimmu.2021.781032
Journal volume & issue: Vol. 12

Abstract

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The activation of stimulator of interferon genes (STING) signalling pathway has been suggested to promote the immune responses against malignancy. STING is activated in response to the detection of cytosolic DNA and can induce type I interferons and link innate immunity with the adaptive immune system. Due to accretive evidence demonstrating that the STING pathway regulates the immune cells of the tumor microenvironment (TME), STING as a cancer biotherapy has attracted considerable attention. Pancreatic cancer, with a highly immunosuppressive TME, remains fatal cancer. STING has been applied to the treatment of pancreatic cancer through distinct strategies. This review reveals the role of STING signalling on pancreatic tumors and other diseases related to the pancreas. We then discuss new advances of STING in either monotherapy or combination methods for pancreatic cancer immunotherapy.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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