Omega-3 polyunsaturated fatty acids and active folates: the prospects of integrated use for pregnancy's nutritional support and malformations prevention (literature review)

Abstract

The active folates and omega-3 polyunsaturated fatty acids (omega-3 PUFAs) effects are often considered separately. At the same time, a pharmacodynamic interaction exists between those essential micronutrients in order to support the full development of the pregnancy and the fetus. Various synergistic interactions of omega-3 fatty acids and folates analysis results, as well as those of fundamental and clinical studies are presented in this paper. The prospects for the combined active folate and omega-3 fatty acids drugs use in pregnancy’s nutritional support and malformations prevention are indicated also.

Keywords

• metafolin
• docosahexaenoic acid (dha)
• the molecular mechanisms
• anti-inflammatory
• neuroprotective
• antiteratogenic synergy
• femibion