The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodeling

Sandipan Brahma; Mzwanele Ngubo; Somnath Paul; Maheshi Udugama; Blaine Bartholomew

doi:10.1038/s41467-018-05710-7

Nature Communications (Aug 2018)

The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodeling

Sandipan Brahma,
Mzwanele Ngubo,
Somnath Paul,
Maheshi Udugama,
Blaine Bartholomew

Affiliations

Sandipan Brahma: Department of Epigenetics & Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center
Mzwanele Ngubo: Department of Epigenetics & Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center
Somnath Paul: Department of Epigenetics & Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center
Maheshi Udugama: Department of Biochemistry and Molecular Biology, Southern Illinois University
Blaine Bartholomew: Department of Epigenetics & Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-018-05710-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

Read online

INO80 chromatin remodeler plays important roles in transcription, DNA repair, recombination, and heterochromatin maintenance. Here the authors characterise the functional interplay between the actin-related proteins (Arps) in INO80, showing that Arp8 and Arp4 module sense the DNA length separating nucleosomes and regulate nucleosome remodeling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal