Frontiers in Microbiology (Mar 2023)
A scoring system based on novel biomarkers and clinical risk factors to predict invasive candidiasis in immunocompetent critically ill patients
- Wen Li,
- Wen Li,
- Wen Li,
- Wen Li,
- Wen Li,
- Gang Chen,
- Gang Chen,
- Gang Chen,
- Gang Chen,
- Gang Chen,
- Fengyu Lin,
- Fengyu Lin,
- Fengyu Lin,
- Fengyu Lin,
- Fengyu Lin,
- Hang Yang,
- Hang Yang,
- Hang Yang,
- Hang Yang,
- Hang Yang,
- Yanhui Cui,
- Yanhui Cui,
- Yanhui Cui,
- Yanhui Cui,
- Yanhui Cui,
- Rongli Lu,
- Rongli Lu,
- Rongli Lu,
- Rongli Lu,
- Rongli Lu,
- Chao Song,
- Haitao Li,
- Yi Li,
- Yi Li,
- Yi Li,
- Yi Li,
- Yi Li,
- Pinhua Pan,
- Pinhua Pan,
- Pinhua Pan,
- Pinhua Pan,
- Pinhua Pan
Affiliations
- Wen Li
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Wen Li
- Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China
- Wen Li
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Wen Li
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Wen Li
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- Gang Chen
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Gang Chen
- Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China
- Gang Chen
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Gang Chen
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Gang Chen
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- Fengyu Lin
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Fengyu Lin
- Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China
- Fengyu Lin
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Fengyu Lin
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Fengyu Lin
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- Hang Yang
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Hang Yang
- Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China
- Hang Yang
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Hang Yang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Hang Yang
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- Yanhui Cui
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Yanhui Cui
- Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China
- Yanhui Cui
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Yanhui Cui
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Yanhui Cui
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- Rongli Lu
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Rongli Lu
- Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China
- Rongli Lu
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Rongli Lu
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Rongli Lu
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- Chao Song
- Nosocomial Infection Control Center, Xiangya Hospital, Central South University, Changsha, China
- Haitao Li
- First Department of Thoracic Medicine, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- Yi Li
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Yi Li
- Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China
- Yi Li
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Yi Li
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Yi Li
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- Pinhua Pan
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Pinhua Pan
- Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China
- Pinhua Pan
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Pinhua Pan
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Pinhua Pan
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- DOI
- https://doi.org/10.3389/fmicb.2023.1097574
- Journal volume & issue
-
Vol. 14
Abstract
BackgroundDelayed diagnosis further increases the mortality of invasive candidiasis (IC) in intensive care unit (ICU) patients. This study aimed to develop and validate a score based on novel serological biomarkers and clinical risk factors for predicting IC in immunocompetent ICU patients.MethodsWe retrospectively collected clinical data and novel serological markers on admission to ICU. Multivariate logistic regression was used to identify the risk factors associated with IC, which were adopted to establish a scoring system.ResultsPatients with IC had a higher C-reactive protein-to-albumin ratio (CAR) and neutrophil-to-lymphocyte ratio (NLR) and lower prognostic nutritional index than those without IC. The NLR, CAR, sepsis, total parenteral nutrition, 1,3-β-D-glucan (BDG)-positivity, and Sequential Organ Failure Assessment score were identified as independent risk factors for IC by multivariate logistic regression analysis and entered into the final scoring system. The area under receiver operating characteristic curve of the score were 0.883 and 0.892, respectively, in the development and validation cohort, higher than Candida score (0.883 vs.0.730, p < 0.001).ConclusionWe established a parsimonious score based on NLR, CAR, BDG-positivity, and clinical risk factors, which can accurately identify IC in ICU patients to give treatment on time and reduce mortality.
Keywords
- invasive candidiasis
- scoring system
- immunocompetent
- novel serological biomarkers
- critically ill patients
