Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis

Hui-Ming Chen; Hui-Ming Chen; Hang Li; Meng-Xian Lin; Wei-Jie Fan; Yi Zhang; Yan-Ting Lin; Yan-Ting Lin; Shu-Xiang Wu; Shu-Xiang Wu

doi:10.3389/fgene.2022.952667

Frontiers in Genetics (Jul 2022)

Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis

Hui-Ming Chen,
Hui-Ming Chen,
Hang Li,
Meng-Xian Lin,
Wei-Jie Fan,
Yi Zhang,
Yan-Ting Lin,
Yan-Ting Lin,
Shu-Xiang Wu,
Shu-Xiang Wu

Affiliations

Hui-Ming Chen: Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
Hui-Ming Chen: Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China
Hang Li: Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
Meng-Xian Lin: Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
Wei-Jie Fan: Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
Yi Zhang: Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
Yan-Ting Lin: Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
Yan-Ting Lin: Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China
Shu-Xiang Wu: Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
Shu-Xiang Wu: Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China

DOI: https://doi.org/10.3389/fgene.2022.952667
Journal volume & issue: Vol. 13

Abstract

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As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate. As high-throughput sequencing and antibody technologies advanced by leaps and bounds, the association of RNA modifications with multiple human diseases sparked research enthusiasm; in addition, aberrant RNA modification leads to tumor angiogenesis by regulating angiogenesis-related factors. This review collected recent cutting-edge studies focused on RNA modifications (N6-methyladenosine (m6A), N5-methylcytosine (m5C), N7-methylguanosine (m7G), N1-methyladenosine (m1A), and pseudopuridine (Ψ)), and their related regulators in tumor angiogenesis to emphasize the role and impact of RNA modifications.

Published in Frontiers in Genetics

ISSN: 1664-8021 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: http://journal.frontiersin.org/journal/genetics

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