Biomarker Research (May 2023)
Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1
- Xiang Zhou,
- Seungbin Han,
- Nadine Cebulla,
- Larissa Haertle,
- Maximilian J. Steinhardt,
- Daniel Schirmer,
- Eva Runau,
- Leon Flamm,
- Calvin Terhorst,
- Laura Jähnel,
- Cornelia Vogt,
- Silvia Nerreter,
- Eva Teufel,
- Emilia Stanojkovska,
- Julia Mersi,
- Umair Munawar,
- Magnus Schindehütte,
- Robert Blum,
- Ann-Kristin Reinhold,
- Oliver Scherf-Clavel,
- Heike L. Rittner,
- Mirko Pham,
- Leo Rasche,
- Hermann Einsele,
- Claudia Sommer,
- K. Martin Kortüm
Affiliations
- Xiang Zhou
- Department of Internal Medicine II, University Hospital of Würzburg
- Seungbin Han
- Department of Internal Medicine II, University Hospital of Würzburg
- Nadine Cebulla
- Department of Neurology, University Hospital of Würzburg
- Larissa Haertle
- Department of Internal Medicine II, University Hospital of Würzburg
- Maximilian J. Steinhardt
- Department of Internal Medicine II, University Hospital of Würzburg
- Daniel Schirmer
- Department of Neurology, University Hospital of Würzburg
- Eva Runau
- Department of Neurology, University Hospital of Würzburg
- Leon Flamm
- Department of Neurology, University Hospital of Würzburg
- Calvin Terhorst
- Department of Neurology, University Hospital of Würzburg
- Laura Jähnel
- Department of Neurology, University Hospital of Würzburg
- Cornelia Vogt
- Department of Internal Medicine II, University Hospital of Würzburg
- Silvia Nerreter
- Department of Internal Medicine II, University Hospital of Würzburg
- Eva Teufel
- Department of Internal Medicine II, University Hospital of Würzburg
- Emilia Stanojkovska
- Department of Internal Medicine II, University Hospital of Würzburg
- Julia Mersi
- Department of Internal Medicine II, University Hospital of Würzburg
- Umair Munawar
- Department of Internal Medicine II, University Hospital of Würzburg
- Magnus Schindehütte
- Department of Neuroradiology, University Hospital of Würzburg
- Robert Blum
- Department of Neurology, University Hospital of Würzburg
- Ann-Kristin Reinhold
- Center for Interdisciplinary Medicine, Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital of Würzburg
- Oliver Scherf-Clavel
- Department of Clinical Pharmacy, University of Würzburg
- Heike L. Rittner
- Center for Interdisciplinary Medicine, Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital of Würzburg
- Mirko Pham
- Department of Neuroradiology, University Hospital of Würzburg
- Leo Rasche
- Department of Internal Medicine II, University Hospital of Würzburg
- Hermann Einsele
- Department of Internal Medicine II, University Hospital of Würzburg
- Claudia Sommer
- Department of Neurology, University Hospital of Würzburg
- K. Martin Kortüm
- Department of Internal Medicine II, University Hospital of Würzburg
- DOI
- https://doi.org/10.1186/s40364-023-00490-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 4
Abstract
Abstract We analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger sequencing in 88 patients with multiple myeloma treated with bortezomib. All patients (n = 13) harboring a homozygous mutation in PKNOX1 (rs2839629) also had a homozygous mutated rs915854 genotype. Homozygous mutated genotypes of rs2839629 and rs915854 were significantly enriched in patients with painful peripheral neuropathy (PNP) (P < 0.0001), and homozygous mutated rs2839629 genotype was significantly enriched in patients with pain compared to patients with no pain (P = 0.04). In summary, both SNPs rs2839629 and/or rs915854 may be potential biomarkers predicting an increased risk to develop painful PNP under bortezomib.
Keywords
