Lipidomic and in-gel analysis of maleic acid co-polymer nanodiscs reveals differences in composition of solubilized membranes

Abstract

Barniol-Xicota and Verhelst investigate the usefulness of different maleic acid-based copolymers (xMAs) to solubilize membrane proteins within native-like lipid environments. They use bacterial and mammalian cell lines to study different polymer solubilisation efficiencies and focus on resultant protein content, protein-lipid ratio, and the lipid compositions obtained within the xMA nanoparticles.