Effect of Catecholamines on Haemostasis Indicators in Coronary Heart Disease

Abstract

The concentration of catecholamines, having positive inotropic and chronotropic effects on heart function, increases under the actionof strong stimuli. This mechanism of influence is very important in terms of the development of both coronary and non-coronarymyocardial damage. However, further studies have revealed an important role of catecholamines in the regulation of hemostasisprocesses, which is very relevant in patients with coronary heart disease, as it increases the risk of myocardial infarction.Aim. Based on the literature data, to study the role of catecholamines in the regulation of the hemostasis system as a risk factor forcomplications in coronary heart disease.Material and methods. We analyzed literature sources in the computer databases «Cyberlennica», «PubMed», «eLibrary» usingthe search words: «сatecholamines – hemostasis», «сatecholamines – platelets», «сatecholamines – leukocytes», «coronary heartdisease – сatecholamines», «coronary heart disease – hemostasis», «coronary heart disease – platelets». The analyzed literaturedescribes the results of original studies that characterize the multifactorial influence of catecholamines on the hemostasis system inthe coronary heart disease: the effects of these hormones as an important activator of the platelet hemostasis, the role of plateletsin activating the coagulation component of hemostasis and its specific features, the importance of leukocytes, erythrocytes,endothelium, changes in the lipid profile in disorders of the blood coagulation process. Therefore, regular monitoring of itscondition, timely pharmacological correction is necessary to ensure effective relapse prevention and reduce the risk of complicationsand fatal outcome.Conclusion. Regular monitoring of the hemostasis system and timely pharmacological correction are necessary to ensure effectiverelapse prevention and reduce the risk of complications and fatal outcome in patients with coronary heart disease.

Keywords

• сatecholamines
• coronary heart disease
• myocardial infarction
• angina pectoris
• platelets
• coagulation hemostasis
• endothelial dysfunction