Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury

Viacheslav V. Andrianov; Vladimir A. Kulchitsky; Guzel G. Yafarova; Leah V. Bazan; Tatiana K. Bogodvid; Irina B. Deryabina; Lyudmila N. Muranova; Dinara I. Silantyeva; Almaz I. Arslanov; Mikhail N. Paveliev; Ekaterina V. Fedorova; Tatiana A. Filipovich; Aleksei V. Nagibov; Khalil L. Gainutdinov

doi:10.3390/molecules28217359

Molecules (Oct 2023)

Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury

Viacheslav V. Andrianov,
Vladimir A. Kulchitsky,
Guzel G. Yafarova,
Leah V. Bazan,
Tatiana K. Bogodvid,
Irina B. Deryabina,
Lyudmila N. Muranova,
Dinara I. Silantyeva,
Almaz I. Arslanov,
Mikhail N. Paveliev,
Ekaterina V. Fedorova,
Tatiana A. Filipovich,
Aleksei V. Nagibov,
Khalil L. Gainutdinov

Affiliations

Viacheslav V. Andrianov: Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia
Vladimir A. Kulchitsky: Brain Center, Institute of Physiology, National Academy of Sciences, 220012 Minsk, Belarus
Guzel G. Yafarova: Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia
Leah V. Bazan: Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia
Tatiana K. Bogodvid: Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia
Irina B. Deryabina: Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia
Lyudmila N. Muranova: Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia
Dinara I. Silantyeva: Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia
Almaz I. Arslanov: Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia
Mikhail N. Paveliev: Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
Ekaterina V. Fedorova: Brain Center, Institute of Physiology, National Academy of Sciences, 220012 Minsk, Belarus
Tatiana A. Filipovich: Brain Center, Institute of Physiology, National Academy of Sciences, 220012 Minsk, Belarus
Aleksei V. Nagibov: Brain Center, Institute of Physiology, National Academy of Sciences, 220012 Minsk, Belarus
Khalil L. Gainutdinov: Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia

DOI: https://doi.org/10.3390/molecules28217359
Journal volume & issue: Vol. 28, no. 21
p. 7359

Abstract

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Nitric oxide (NO) production in injured and intact brain regions was compared by EPR spectroscopy in a model of brain and spinal cord injury in Wistar rats. The precentral gyrus of the brain was injured, followed by the spinal cord at the level of the first lumbar vertebra. Seven days after brain injury, a reduction in NO content of 84% in injured brain regions and 66% in intact brain regions was found. The difference in NO production in injured and uninjured brain regions persisted 7 days after injury. The copper content in the brain remained unchanged one week after modeling of brain and spinal cord injury. The data obtained in the experiments help to explain the problems in the therapy of patients with combined brain injury.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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