ERECTYLE DYSFUNCTION AS EARLY PREDICTOR FOR CARDIOVASCULAR DISEASES IN MEN WITH OBSTRUCTIVE SLEEP APNEA SYNDROME

Abstract

Aim. To evaluate the pattern of nocturnal penile episodes during polysomnography and the lipid profile for the risk of cardiovascular diseases development in men with OSAS.Material and methods. Totally 51 men aged 46-55 years participated in the study. After enhanced PSG by the GRASS-TELEFACTOR Twin PSG (Comet) system with As 40 amplifier and integrated module SPM-1 (USA) with in-built into the software option for nocturnal penile episodes (NPT) registration the participants were divided into 2 gropus. First 37 men made up the group of OSAS patients (av. age 53,16±3,45 y., body mass index — 33,19±5,76 kg/m2). Other 14 men were the control, with the same age and BMI, but free from respiration disorders during the night sleep. The serum utilized as the specimen for chemistry. Results. In men with OSAS the disorderd sleep structure was found, represented by significant prevalence of low-deepness sleep, deep sleep deficiency and lack of REM sleep. Also there was impairment of night spontaneous erection during REM sleep — retardation of the beginning and prolongation of detumescence. The quantity of NPT was lower during the sleep. Lipid profile showed lower levels of antiatherogenic and increased levels of atherogenic cholesterol fractions with increased atherogenity index. Relative risk for cardiovascular pathology was 4 times higher in patients erectile dysfunction (RR=3,9; 95% CI 1,44-10,61). Attributive risk for ED in regard to cardiovascular pathology was 66% (95% CI 44,6%-87,4%). Conclusion. The results make possible to regard the ED in OSAS as early predictor for cardiovascular pathology in men.

Keywords

• erectile dysfunction
• obstructive sleep apnea syndrome
• lipid profile
• atherosclerosis