Thermo-responsive triple-function nanotransporter for efficient chemo-photothermal therapy of multidrug-resistant bacterial infection

Guangchao Qing; Xianxian Zhao; Ningqiang Gong; Jing Chen; Xianlei Li; Yaling Gan; Yongchao Wang; Zhen Zhang; Yuxuan Zhang; Weisheng Guo; Yang Luo; Xing-Jie Liang

doi:10.1038/s41467-019-12313-3

Nature Communications (Sep 2019)

Thermo-responsive triple-function nanotransporter for efficient chemo-photothermal therapy of multidrug-resistant bacterial infection

Guangchao Qing,
Xianxian Zhao,
Ningqiang Gong,
Jing Chen,
Xianlei Li,
Yaling Gan,
Yongchao Wang,
Zhen Zhang,
Yuxuan Zhang,
Weisheng Guo,
Yang Luo,
Xing-Jie Liang

Affiliations

Guangchao Qing: Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, College of Bioengineering, Chongqing University
Xianxian Zhao: Department of Clinical Laboratory Medicine, Southwest Hospital, Army Medical University
Ningqiang Gong: Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China
Jing Chen: Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China
Xianlei Li: Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China
Yaling Gan: Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China
Yongchao Wang: Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China
Zhen Zhang: Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China
Yuxuan Zhang: Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China
Weisheng Guo: Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Second Affiliated Hospital, Guangzhou Medical University
Yang Luo: Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, College of Bioengineering, Chongqing University
Xing-Jie Liang: Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China

DOI: https://doi.org/10.1038/s41467-019-12313-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Antibiotic resistance is a major global health challenge. Here, the authors report on a thermoresponsive delivery system for combined photothermal and antibiotic delivery with fluorescent tracking abilities and demonstrate application against antibiotic resistant bacteria in vitro and in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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