Characterization of genetic subclonal evolution in pancreatic cancer mouse models

Noushin Niknafs; Yi Zhong; John Alec Moral; Lance Zhang; Melody Xiaoshan Shao; April Lo; Alvin Makohon-Moore; Christine A. Iacobuzio-Donahue; Rachel Karchin

doi:10.1038/s41467-019-13100-w

Nature Communications (Nov 2019)

Characterization of genetic subclonal evolution in pancreatic cancer mouse models

Noushin Niknafs,
Yi Zhong,
John Alec Moral,
Lance Zhang,
Melody Xiaoshan Shao,
April Lo,
Alvin Makohon-Moore,
Christine A. Iacobuzio-Donahue,
Rachel Karchin

Affiliations

Noushin Niknafs: Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University
Yi Zhong: Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
John Alec Moral: Department of Surgery, Memorial Sloan Kettering Cancer Center
Lance Zhang: Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Melody Xiaoshan Shao: Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University
April Lo: Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University
Alvin Makohon-Moore: Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Christine A. Iacobuzio-Donahue: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Rachel Karchin: Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University

DOI: https://doi.org/10.1038/s41467-019-13100-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

Read online

In pancreatic cancer the Kras and Trp53 transgene driven KPC mouse model is used to experimentally study disease processes. Here, the authors analyse tumour evolution within the KPC model, finding both linear and branched evolution and highlighting the utility of this model in mechanistic research of tumour evolution.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal