Nature Communications (Oct 2022)
Human papillomavirus integration perspective in small cell cervical carcinoma
- Xiaoli Wang,
- Wenlong Jia,
- Mengyao Wang,
- Jihong Liu,
- Xianrong Zhou,
- Zhiqing Liang,
- Qinghua Zhang,
- Sixiang Long,
- Suolang Quzhen,
- Xiangchun Li,
- Qiang Tian,
- Xiong Li,
- Haiying Sun,
- Caili Zhao,
- Silu Meng,
- Ruoqi Ning,
- Ling Xi,
- Lin Wang,
- Shasha Zhou,
- Jianwei Zhang,
- Li Wu,
- Yile Chen,
- Aijun Liu,
- Yaqi Ma,
- Xia Zhao,
- Xiaodong Cheng,
- Qing Zhang,
- Xiaobing Han,
- Huaxiong Pan,
- Yuan Zhang,
- Lili Cao,
- Yiqin Wang,
- Shaoping Ling,
- Lihua Cao,
- Hui Xing,
- Chang Xu,
- Long Sui,
- Shixuan Wang,
- Jianfeng Zhou,
- Beihua Kong,
- Xing Xie,
- Gang Chen,
- Shuaicheng Li,
- Ding Ma,
- Shuang Li
Affiliations
- Xiaoli Wang
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Wenlong Jia
- City University of Hong Kong Shenzhen Research Institute
- Mengyao Wang
- City University of Hong Kong Shenzhen Research Institute
- Jihong Liu
- Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Xianrong Zhou
- Obstetrics and Gynecology Hospital of Fudan University
- Zhiqing Liang
- Department of Gynecologic Oncology, Southwest Hospital, Third Military Medical University
- Qinghua Zhang
- Department of Gynecology & Obstetrics, The Central Hospital of Wuhan
- Sixiang Long
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Suolang Quzhen
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Xiangchun Li
- Tianjin Cancer Institute, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital
- Qiang Tian
- National Infrastructures of Translational Medicine (Shanghai), Shanghai JiaoTong University School of Medicine
- Xiong Li
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Haiying Sun
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Caili Zhao
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Silu Meng
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Ruoqi Ning
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Ling Xi
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Lin Wang
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Shasha Zhou
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Jianwei Zhang
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Li Wu
- Department of Gynecologic Oncology, Hunan ProvinceTumor Hospital
- Yile Chen
- Department of Gynecologic Oncology, Hunan ProvinceTumor Hospital
- Aijun Liu
- Department of Pathology, Chinese People’s Liberation Army General Hospital
- Yaqi Ma
- Department of Pathology, Chinese People’s Liberation Army General Hospital
- Xia Zhao
- Department of Gynecologic Oncology, West China Second Hospital, Sichuan University
- Xiaodong Cheng
- Women’s Reproductive Health Laboratory of Zhejiang Province
- Qing Zhang
- Department of Gynecology & Obstetrics, Qilu Hospital, Shandong University
- Xiaobing Han
- Department of Obstetrics and Gynecology, the First Affiliated Hospital, Medical School of Xi’an Jiaotong University
- Huaxiong Pan
- UnionHospital, Tongji Medical College, Huazhong University of Science and Technology
- Yuan Zhang
- UnionHospital, Tongji Medical College, Huazhong University of Science and Technology
- Lili Cao
- Department of Gynecology & Obstetrics, The Central Hospital of Wuhan
- Yiqin Wang
- Department of Gynecologic Oncology, Southwest Hospital, Third Military Medical University
- Shaoping Ling
- Genome Wisdom Inc.
- Lihua Cao
- Genome Wisdom Inc.
- Hui Xing
- Department of Obstetrics and Gynecology, Xiangfan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Chang Xu
- City University of Hong Kong Shenzhen Research Institute
- Long Sui
- Obstetrics and Gynecology Hospital of Fudan University
- Shixuan Wang
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Jianfeng Zhou
- Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Beihua Kong
- Department of Gynecology & Obstetrics, Qilu Hospital, Shandong University
- Xing Xie
- Women’s Reproductive Health Laboratory of Zhejiang Province
- Gang Chen
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Shuaicheng Li
- City University of Hong Kong Shenzhen Research Institute
- Ding Ma
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Shuang Li
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-022-33359-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
Small cell cervical carcinoma (SCCC) is a rare but aggressive malignancy. Here, the authors report human papillomavirus features and genomic landscape in SCCC via high-throughput sequencing methods and identify MYC, SOX, NR4A, ANKRD and CEA family genes as HPV-integrated hotspots.
