Nature Communications (Aug 2022)
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
- Dominik Saul,
- Robyn Laura Kosinsky,
- Elizabeth J. Atkinson,
- Madison L. Doolittle,
- Xu Zhang,
- Nathan K. LeBrasseur,
- Robert J. Pignolo,
- Paul D. Robbins,
- Laura J. Niedernhofer,
- Yuji Ikeno,
- Diana Jurk,
- João F. Passos,
- LaTonya J. Hickson,
- Ailing Xue,
- David G. Monroe,
- Tamara Tchkonia,
- James L. Kirkland,
- Joshua N. Farr,
- Sundeep Khosla
Affiliations
- Dominik Saul
- Division of Endocrinology, Mayo Clinic
- Robyn Laura Kosinsky
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Elizabeth J. Atkinson
- Department of Quantitative Health Sciences, Mayo Clinic
- Madison L. Doolittle
- Division of Endocrinology, Mayo Clinic
- Xu Zhang
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Nathan K. LeBrasseur
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Robert J. Pignolo
- Division of Endocrinology, Mayo Clinic
- Paul D. Robbins
- Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota
- Laura J. Niedernhofer
- Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota
- Yuji Ikeno
- Department of Pathology, University of Texas Health
- Diana Jurk
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- João F. Passos
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- LaTonya J. Hickson
- Division of Nephrology and Hypertension, Mayo Clinic
- Ailing Xue
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- David G. Monroe
- Division of Endocrinology, Mayo Clinic
- Tamara Tchkonia
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- James L. Kirkland
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Joshua N. Farr
- Division of Endocrinology, Mayo Clinic
- Sundeep Khosla
- Division of Endocrinology, Mayo Clinic
- DOI
- https://doi.org/10.1038/s41467-022-32552-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Identification of senescent cells in vivo remains a challenging task. Here the authors present and validate a senescence gene set called SenMayo enriched in human and murine aged tissues.
