Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor

Mayank Srivastava; Ying Zhang; Jian Chen; Devika Sirohi; Andrew Miller; Yang Zhang; Zhilu Chen; Haojie Lu; Jianqing Xu; Richard J. Kuhn; W. Andy Tao

doi:10.1038/s41467-020-17638-y

Nature Communications (Aug 2020)

Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor

Mayank Srivastava,
Ying Zhang,
Jian Chen,
Devika Sirohi,
Andrew Miller,
Yang Zhang,
Zhilu Chen,
Haojie Lu,
Jianqing Xu,
Richard J. Kuhn,
W. Andy Tao

Affiliations

Mayank Srivastava: Department of Chemistry, Purdue University
Ying Zhang: Institutes of Biomedical Sciences and NHC Key Laboratory of Glycoconjugates Research, Fudan University
Jian Chen: Shanghai Public Health Clinical Center, Fudan University
Devika Sirohi: Department of Biological Sciences, Purdue University
Andrew Miller: Department of Biological Sciences, Purdue University
Yang Zhang: Institutes of Biomedical Sciences and NHC Key Laboratory of Glycoconjugates Research, Fudan University
Zhilu Chen: Institutes of Biomedical Sciences and NHC Key Laboratory of Glycoconjugates Research, Fudan University
Haojie Lu: Institutes of Biomedical Sciences and NHC Key Laboratory of Glycoconjugates Research, Fudan University
Jianqing Xu: Institutes of Biomedical Sciences and NHC Key Laboratory of Glycoconjugates Research, Fudan University
Richard J. Kuhn: Department of Biological Sciences, Purdue University
W. Andy Tao: Department of Chemistry, Purdue University

DOI: https://doi.org/10.1038/s41467-020-17638-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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The mechanism underlying the cellular entry of Zika virus is not fully understood. Here, the authors use a chemically modified virus and time-resolved proteomics to capture interacting host proteins during virus entry and identify NCAM1 as a ZIKV receptor.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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