Citrate-based fluorometric sensor for multi-halide sensing

Dingbowen Wang; Tunan Xia; Yuqi Wang; Yizhu Chen; Chenji Zhang; William Murray; Adam Thomas Schultz; Zhiwen Liu; Jian Yang

Smart Materials in Medicine (Jan 2022)

Citrate-based fluorometric sensor for multi-halide sensing

Dingbowen Wang,
Tunan Xia,
Yuqi Wang,
Yizhu Chen,
Chenji Zhang,
William Murray,
Adam Thomas Schultz,
Zhiwen Liu,
Jian Yang

Affiliations

Dingbowen Wang: Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA
Tunan Xia: Department of Electrical Engineering, Materials Research Institute, The Pennsylvania State University, University Park, PA, 16802, USA
Yuqi Wang: Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA
Yizhu Chen: Department of Electrical Engineering, Materials Research Institute, The Pennsylvania State University, University Park, PA, 16802, USA
Chenji Zhang: Department of Electrical Engineering, Materials Research Institute, The Pennsylvania State University, University Park, PA, 16802, USA
William Murray: Department of Electrical Engineering, Materials Research Institute, The Pennsylvania State University, University Park, PA, 16802, USA
Adam Thomas Schultz: Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA
Zhiwen Liu: Department of Electrical Engineering, Materials Research Institute, The Pennsylvania State University, University Park, PA, 16802, USA; Corresponding author.
Jian Yang: Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA; Corresponding author.

Journal volume & issue: Vol. 3
pp. 374 – 381

Abstract

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Halides play important roles in human health and environmental monitoring. However, different halides interfere with each other in current measurement methods. Simultaneous sensing of multiple halides in a fast and low-cost manner remains a challenge. Here, we report a fluorometric multi-halide sensing method by using a single citrate-based fluorophore, CA-Cys, on a custom-made portable device. The fluorescence emitted by CA-Cys is quenched due to the dynamic quenching of halide ions; the sensitivities vary from halide types and pH, providing the capability to obtain multiple Stern-Volmer equations at various pH values. The concentration of each halide can then be obtained by solving the resultant set of equations. A mM scale detection limit is demonstrated, which is suitable for halide wastewater monitoring. A proof-of-concept smartphone-based portable device is also fabricated and tested. The results from the fluorometer and portable device indicated that our multi-halide system is promising for real-world multi-halide sensing applications. This work represents a new direction in developing portable, low-cost, and simultaneous multi-halide sensing technologies.

Published in Smart Materials in Medicine

ISSN: 2590-1834 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology
Website: https://www.keaipublishing.com/en/journals/smart-materials-in-medicine/

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