Metabolites (Dec 2022)
Associations between Periodontitis, COVID-19, and Cardiometabolic Complications: Molecular Mechanisms and Clinical Evidence
- Giuseppe Mainas,
- Luigi Nibali,
- Mark Ide,
- Wael Al Mahmeed,
- Khalid Al-Rasadi,
- Kamila Al-Alawi,
- Maciej Banach,
- Yajnavalka Banerjee,
- Antonio Ceriello,
- Mustafa Cesur,
- Francesco Cosentino,
- Alberto Firenze,
- Massimo Galia,
- Su-Yen Goh,
- Andrej Janež,
- Sanjay Kalra,
- Nitin Kapoor,
- Peter Kempler,
- Nader Lessan,
- Paulo Lotufo,
- Nikolaos Papanas,
- Ali A. Rizvi,
- Amirhossein Sahebkar,
- Raul D. Santos,
- Anca P. Stoian,
- Peter P. Toth,
- Vijay Viswanathan,
- Manfredi Rizzo
Affiliations
- Giuseppe Mainas
- Periodontology Unit, Centre for Host-Microbiome Interactions, Dental Institute, King’s College London, London SE1 9RT, UK
- Luigi Nibali
- Periodontology Unit, Centre for Host-Microbiome Interactions, Dental Institute, King’s College London, London SE1 9RT, UK
- Mark Ide
- Periodontology Unit, Centre for Host-Microbiome Interactions, Dental Institute, King’s College London, London SE1 9RT, UK
- Wael Al Mahmeed
- Heart and Vascular Institute, Cleveland Clinic, Abu Dhabi P.O. Box 112412, United Arab Emirates
- Khalid Al-Rasadi
- Medical Research Center, Sultan Qaboos University, Muscat 113, Oman
- Kamila Al-Alawi
- Department of Training and Studies, Royal Hospital, Ministry of Health, Muscat 113, Oman
- Maciej Banach
- Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), 90419 Lodz, Poland
- Yajnavalka Banerjee
- Department of Biochemistry, Mohamed Bin Rashid University, Dubai 505055, United Arab Emirates
- Antonio Ceriello
- IRCCS MultiMedica, 20099 Milan, Italy
- Mustafa Cesur
- Clinic of Endocrinology, Ankara Güven Hospital, 06540 Ankara, Turkey
- Francesco Cosentino
- Unit of Cardiology, Karolinska Institute and Karolinska University Hospital, University of Stockholm, 17177 Stockholm, Sweden
- Alberto Firenze
- Unit of Research and International Cooperation, University Hospital of Palermo, 90133 Palermo, Italy
- Massimo Galia
- Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bind), University of Palermo, 90133 Palermo, Italy
- Su-Yen Goh
- Department of Endocrinology, Singapore General Hospital, Singapore 169856, Singapore
- Andrej Janež
- Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center Ljubljana, 1000 Ljubljana, Slovenia
- Sanjay Kalra
- Department of Endocrinology, Bharti Hospital & BRIDE, Karnal 132001, India
- Nitin Kapoor
- Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore 632004, India
- Peter Kempler
- Department of Medicine and Oncology, Semmelweis University, 1085 Budapest, Hungary
- Nader Lessan
- The Research Institute, Imperial College London Diabetes Centre, Abu Dhabi P.O. Box 48338, United Arab Emirates
- Paulo Lotufo
- Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo 05508-000, Brazil
- Nikolaos Papanas
- Diabetes Center, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece
- Ali A. Rizvi
- Department of Medicine, University of Central Florida College of Medicine, Orlando, FL 32827, USA
- Amirhossein Sahebkar
- Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad 1313199137, Iran
- Raul D. Santos
- Heart Institute (InCor) University of Sao Paulo Medical School Hospital, São Paulo 05403-900, Brazil
- Anca P. Stoian
- Faculty of Medicine, Diabetes, Nutrition and Metabolic Diseases, Carol Davila University, 050474 Bucharest, Romania
- Peter P. Toth
- Cicarrone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
- Vijay Viswanathan
- Diabetes Research Centre, Chennai 600013, India
- Manfredi Rizzo
- Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (Promise), University of Palermo, 90133 Palermo, Italy
- DOI
- https://doi.org/10.3390/metabo13010040
- Journal volume & issue
-
Vol. 13,
no. 1
p. 40
Abstract
Periodontitis is a microbially driven, host-mediated disease that leads to loss of periodontal attachment and resorption of bone. It is associated with the elevation of systemic inflammatory markers and with the presence of systemic comorbidities. Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although the majority of patients have mild symptoms, others experience important complications that can lead to death. After the spread of the COVID-19 pandemic, several investigations demonstrating the possible relationship between periodontitis and COVID-19 have been reported. In addition, both periodontal disease and COVID-19 seem to provoke and/or impair several cardiometabolic complications such as cardiovascular disease, type 2 diabetes, metabolic syndrome, dyslipidemia, insulin resistance, obesity, non-alcoholic fatty liver disease, and neurological and neuropsychiatric complications. Therefore, due to the increasing number of investigations focusing on the periodontitis-COVID-19 relationship and considering the severe complications that such an association might cause, this review aims to summarize all existing emerging evidence regarding the link between the periodontitis-COVID-19 axis and consequent cardiometabolic impairments.
Keywords
