Generation of two induced pluripotent stem cell lines from patients suffering from pulmonary hypertension

Gaoxian Chen; Lorena Orozco; Sophia Parmisano; James W.S. Jahng; Carlos D. Vera; Yan Zhuge; Joseph C. Wu; Detlef Obal

Stem Cell Research (Oct 2023)

Generation of two induced pluripotent stem cell lines from patients suffering from pulmonary hypertension

Gaoxian Chen,
Lorena Orozco,
Sophia Parmisano,
James W.S. Jahng,
Carlos D. Vera,
Yan Zhuge,
Joseph C. Wu,
Detlef Obal

Affiliations

Gaoxian Chen: Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Lorena Orozco: Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Human Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Sophia Parmisano: Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
James W.S. Jahng: Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Carlos D. Vera: Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Yan Zhuge: Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Joseph C. Wu: Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Corresponding authors at: 265 Campus Drive, G1120B, Stanford, CA 94305, United States.
Detlef Obal: Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Corresponding authors at: 265 Campus Drive, G1120B, Stanford, CA 94305, United States.

Journal volume & issue: Vol. 72
p. 103218

Abstract

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Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease, with an estimated 500–1000 new cases diagnosed every year. A portion of these cases may be caused by mutations in the BMPR2 gene, suggesting a possible genetic component in the development of the disease. Here, we report two human induced pluripotent stem cell (iPSC) lines generated from IPAH patients. Both cell lines provide valuable insight into the molecular and cellular mechanisms of IPAH and can be used to further understand the disease.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

About the journal

Abstract

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