Nature Communications (Feb 2018)
Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
- Ladan Khodaparast,
- Laleh Khodaparast,
- Rodrigo Gallardo,
- Nikolaos N. Louros,
- Emiel Michiels,
- Reshmi Ramakrishnan,
- Meine Ramakers,
- Filip Claes,
- Lydia Young,
- Mohammad Shahrooei,
- Hannah Wilkinson,
- Matyas Desager,
- Wubishet Mengistu Tadesse,
- K. Peter R. Nilsson,
- Per Hammarström,
- Abram Aertsen,
- Sebastien Carpentier,
- Johan Van Eldere,
- Frederic Rousseau,
- Joost Schymkowitz
Affiliations
- Ladan Khodaparast
- Laboratory of Clinical Bacteriology and Mycology, Department of Microbiology and Immunology, KULeuven
- Laleh Khodaparast
- Laboratory of Clinical Bacteriology and Mycology, Department of Microbiology and Immunology, KULeuven
- Rodrigo Gallardo
- Switch Laboratory, VIB Center for Brain and Disease Research
- Nikolaos N. Louros
- Switch Laboratory, VIB Center for Brain and Disease Research
- Emiel Michiels
- Switch Laboratory, VIB Center for Brain and Disease Research
- Reshmi Ramakrishnan
- Switch Laboratory, VIB Center for Brain and Disease Research
- Meine Ramakers
- Switch Laboratory, VIB Center for Brain and Disease Research
- Filip Claes
- Switch Laboratory, VIB Center for Brain and Disease Research
- Lydia Young
- Astbury Centre for Structural Molecular Biology, University of Leeds
- Mohammad Shahrooei
- Laboratory of Clinical Bacteriology and Mycology, Department of Microbiology and Immunology, KULeuven
- Hannah Wilkinson
- Switch Laboratory, VIB Center for Brain and Disease Research
- Matyas Desager
- Switch Laboratory, VIB Center for Brain and Disease Research
- Wubishet Mengistu Tadesse
- Laboratory of Food Microbiology, Department of Microbial and Molecular Systems (M²S), KULeuven
- K. Peter R. Nilsson
- Department of Physics, Chemistry and Biology, Linköping University
- Per Hammarström
- Department of Physics, Chemistry and Biology, Linköping University
- Abram Aertsen
- Laboratory of Food Microbiology, Department of Microbial and Molecular Systems (M²S), KULeuven
- Sebastien Carpentier
- Systems Biology based Mass Spectrometry Laboratory (SyBioMa), KULeuven
- Johan Van Eldere
- Laboratory of Clinical Bacteriology and Mycology, Department of Microbiology and Immunology, KULeuven
- Frederic Rousseau
- Switch Laboratory, VIB Center for Brain and Disease Research
- Joost Schymkowitz
- Switch Laboratory, VIB Center for Brain and Disease Research
- DOI
- https://doi.org/10.1038/s41467-018-03131-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Aggregation is sequence-specific and nucleated by short aggregating protein segments (APR). Here authors use a multidisciplinary approach to show that in E.coli some frequently occurring APRs lead to protein aggregation and ultimately bacterial cell death, which could serve as antibacterial strategy.
