Фармакокинетика и Фармакодинамика (Nov 2017)

Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells

  • T. A. Antipova,
  • S. V. Nikolaev,
  • A. V. Revishchin,
  • E. A. Savchenko,
  • G. V. Pavlova,
  • T. A. Gudasheva

Journal volume & issue
Vol. 0, no. 4
pp. 31 – 35

Abstract

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Dimeric dipeptide mimetic 1st loop of NGF GK-6 (10-6M) activating as phosphatidylinozitol 3-kinase/Akt and mitogen-activated protein kinase MEK/MAPK/ERK) signaling cascades causes PC12 cell differentiation into neuron-like cells. At the same time dimeric dipeptide mimetic the 4th loop of NGF GK-2 (10-6M), which activates only phosphatidylinozitol 3-kinase/Akt, does not possess the differentiating effect.

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