Türk Osteoporoz Dergisi (Aug 2021)
The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women
Abstract
Objective:The relationship between bone mineral density (BMD) values and nutritional status as well as serum copper (Cu), zinc (Zn), selenium (Se) and manganese (Mn) levels in postmenopausal women has not been fully elucidated. Therefore, this study aimed to investigate whether there is a relationship between BMD values and nutritional status as well as serum Cu, Zn, Se and Mn levels by evaluating the nutritional status of postmenopausal women based on the BMD values using an objective index.Materials and Methods:The study included 105 postmenopausal women who were divided into the following 3 groups: Controls (control group, n=30, T-score >-1.0), patients with osteopaenia (osteopaenia group, n=30, T-score >-2.5) and patients with osteoporosis (osteoporosis group, n=45, T-score ≤-2.5). Moreover, the nutritional status of the patients was determined using the prognostic nutritional index (PNI), which is calculated based on the serum albumin levels and total lymphocyte count. Further, serum Cu, Zn, Se and Mn levels were also determined. The relationship between BMD and PNI as well as the serum levels of Cu, Zn, Se and Mn was investigated.Results:The mean age and body mass index (BMI) of the participants were found to be similar in all the groups [control group (age, 63.4±5.2 years; BMI, 33.7±5.6 kg/m2); osteopaenia group (age, 64.6±5.3 years; BMI, 33.5±5.9 kg/m2) and osteoporosis group (age, 65.8±5 years; BMI, 30.9±7.2 kg/m2)]. In the osteoporosis group, the PNI and serum albumin, Cu and Zn levels were significantly lower than those in the control group (p<0.05), and a weak positive correlation was observed between lumbar total BMD values and PNI as well as serum albumin and Mn levels (p<0.05). Furthermore, a positive moderate correlation between PNI and serum Zn levels was observed in the osteoporosis group (p=0.045, r=0.063).Conclusion:Low serum albumin levels and a low PNI, particularly in postmenopausal patients with osteoporosis, may have an adverse effect on the total BMD in the lumbar region. Furthermore, Zn supplementation in patients with osteoporosis having low PNI can be a potential additional treatment strategy. Cu and Mn supplementation may also provide an additional benefit to existing treatments.
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