Synthetic promoters to induce immune-effectors into the tumor microenvironment

Yariv Greenshpan; Omri Sharabi; Aner Ottolenghi; Avishag Cahana; Kiran Kundu; Ksenia M. Yegodayev; Moshe Elkabets; Roi Gazit; Angel Porgador

doi:10.1038/s42003-021-01664-7

Communications Biology (Jan 2021)

Synthetic promoters to induce immune-effectors into the tumor microenvironment

Yariv Greenshpan,
Omri Sharabi,
Aner Ottolenghi,
Avishag Cahana,
Kiran Kundu,
Ksenia M. Yegodayev,
Moshe Elkabets,
Roi Gazit,
Angel Porgador

Affiliations

Yariv Greenshpan: Faculty of Health Sciences, The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev
Omri Sharabi: Faculty of Health Sciences, The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev
Aner Ottolenghi: Faculty of Health Sciences, The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev
Avishag Cahana: Faculty of Health Sciences, The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev
Kiran Kundu: Faculty of Health Sciences, The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev
Ksenia M. Yegodayev: Faculty of Health Sciences, The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev
Moshe Elkabets: Faculty of Health Sciences, The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev
Roi Gazit: Faculty of Health Sciences, The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev
Angel Porgador: Faculty of Health Sciences, The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev

DOI: https://doi.org/10.1038/s42003-021-01664-7
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

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Greenshpan et al. explore the use of synthetic promoters based on IFNgamma, TNF alpha and hypoxia responsive elements to control gene expression. The authors describe this technology in the context of chimeric antigen expression (CAR) and propose that this method can circumvent off-target toxic effects via specific expression of the CAR in the tumor microenvironment.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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