New advances in diagnosis and treatment of nano drug delivery systems across the blood-brain barrier

Abstract

AbstractThe blood-brain barrier (BBB) is a multicellular neurovascular unit that serves as a highly impermeable cellular barrier to regulate brain homeostasis, protect the central nervous system, and respond to different physiological and pathological states. Recently, new drugs have been discovered to treat neuropathology. However, because BBB blocks the delivery of drugs to the central nervous system (CNS), it is still difficult to translate the treatment of CNS diseases into clinical results. Therefore, overcoming the BBB and realizing efficient delivery of therapeutic drugs is of great significance for the diagnosis and treatment of various neurological diseases such as Alzheimer’s disease, Parkinson’s disease and glioblastoma. Nano drug delivery system (NDDS) has the characteristics of high biocompatibility, high drug load, improving pharmacokinetic behavior of drugs in vivo, achieving targeted drug delivery, controlled drug release, etc. Therefore, in the field of trans-BBB drug delivery, It has broad application prospect for the diagnosis and treatment of various neurological diseases. This paper reviews the latest research on NDDS crossing BBB at home and abroad, providing new ideas for the diagnosis and treatment of CNS diseases.

Keywords

• Blood-brain barrier (BBB)
• neurological drug delivery
• receptor-mediated transport
• nano drug delivery system (NDDS)
• biomimic membrane
• exosome (Ex)