Asian Pacific Journal of Cancer Care (Mar 2021)

Prevalence of H. pylori Infection in Relatives of Peruvian Patients with Gastric Cancer

  • Miluska Castillo,
  • Luis A. Bernabe,
  • Carlos A. Castaneda,
  • Nancy Suarez,
  • Fernando Barreda,
  • Daniel Valdivia,
  • Eloy Ruiz,
  • Jais Nieves,
  • Emmanuel Dias-Neto,
  • Maria Landa-Baella,
  • Jennifer Montano-Flores,
  • Ivan Chavez

DOI
https://doi.org/10.31557/apjcc.2021.6.1.53-57
Journal volume & issue
Vol. 6, no. 1
pp. 53 – 57

Abstract

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Objective: The aim of this study was to determine the relationship between Helicobacter pylori (H. pylori) infection in relatives and patients with gastric cancer (GC). Methods: H. pylori infection was evaluated by the breath urease test in 171 relatives and by qPCR technique in gastric tissue of 61 patients (n=45 for GC and n=16 for non-GC). Results: There were included 137 relatives of GC patients and 34 of non-GC. The median age of the relatives of patients with a gastric tissue sample was 39 years (10-86). Infection was found in 60.2% (n=103) relatives. There were no higher H. pylori infection rates in relatives of patients with gastric cancer (62% vs 62.9%, p=0.33), H. pylori infection (60% vs 60%, p=0.96), or metaplasia (58.8% vs 61.8%, p=0.71). Conclusion: The prevalence of infection in relatives of GC patients is high in our population but not associated with H. pylori presence in the paired case.

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