Diabetes, Metabolic Syndrome and Obesity (Oct 2022)
Utility of Adipokines and IL-10 in Association with Anthropometry in Prediction of Insulin Resistance in Obese Children
Abstract
Asmaa A El Sehmawy1 *, Fatma Elzhraa Ahmed Diab2 *, Donia Ahmed Hassan2 *, Doaa Sayed Mohammed3 *, Mona Gamal El Din Al Anany4 *, Noha A Eldesoky5 *, Reham Yousri Elamir6 ʡPediatrics Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 2Clinical PAthology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 3Endocrinology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 4Physiology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 5Biochemistry and Molecular Biology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt; 6Public Health and COmmunity Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt*These authors contributed equally to this workCorrespondence: Asmaa A El Sehmawy, Al-Azhar University, Faculty of Medicine, Pediatric Department, Elbehira, Al-Khalifa -Elmamoon street, Cairo, Egypt, Tel +2 01063752905, Fax +0453407042, Email [email protected]: This is a case-controlled study, with two hundred children enrolled. They were divided into an obese group of 100 children who had BMI ≥ 95th percentile according to CDC criteria and a group of 100 children with normal weight. All enrolled children were subjected to detailed medical history and clinical examination, in addition to measuring fasting blood sugar, fasting serum insulin, HOMA-IR calculation, lipid profile analysis, total serum cholesterol, low- and high-density lipoproteins (LDL and HDL), and serum triglyceride (TG). Two adipokines (lipocalin-2 and adipsin) serum levels plus IL-10 serum level were assessed.Results: Higher Z score of weight, MI, and waist/height ratio and high serum cholesterol, LDL, TG, and low HDL were observed in obese children. Higher levels of serum lipocalin-2 and adipsin and lower IL-10 blood level were observed in the obese group in comparison with the normal weight children. Higher insulin resistance index was observed in the obese group, with positive correlation of HOMA-IR with the anthropometric measurements and lipocalin serum level, while negative correlation was observed between IL-10 and fasting insulin in obese children.Conclusion: Simple measurement of general and central adiposity markers and serum lipocalin-2 can predict insulin resistance in obese children while serum adipsin and IL-10 had no association with insulin resistance.Keywords: adipokines, IL10, insulin resistance, obesity
