مجله علوم پزشکی فیض (پیوسته) (Apr 2024)
Association between ACE gene deletion/insertion polymorphism and mitral valve prolapse in Mazandaran Province, Northern Iran
Abstract
Background and Aim: Mitral valve prolapse is a cardiac condition affecting the valve between the heart's left chambers, with genetic factors playing a significant role. This study aimed to assess the relationship between ACE gene deletion/insertion polymorphism and mitral valve prolapse in Mazandaran Province, located in northern Iran. Methods: This case-control study included 90 patients with mitral valve prolapse and 95 healthy individuals as the control group. Genomic DNA was extracted from blood leukocytes, and genotypes and allelic frequencies were determined using the GAP-PCR method. Results: The frequencies of II, ID, and DD genotypes of the ACE gene in patients were 22.22%, 42.22%, and 35.46%, respectively, while in the control group, they were 32.63%, 45.26%, and 22.1%, respectively. A statistically significant difference was observed in the frequency of the DD genotype in patients compared to the control group (P=0.048, CI=1.00-3.70, OR=1.92). The odds ratio indicated that the D allele increased the probability of mitral valve prolapse by 1.58 times more than the I allele (OR=1.58). Furthermore, the frequency of the DD genotype was significantly higher in patients with high blood pressure (33.9%) compared to those without high blood pressure (12.7%) (P=0.02). Conclusion: The results suggest a potential association between the I/D polymorphism of the ACE gene and mitral valve prolapse. However, further studies involving larger populations are necessary to confirm these findings.
