PHARMACOKINETICS OF CEFTRIAXONE FOLLOWING INTRAMUSCULAR ADMINISTRATION IN LOCAL PIG OF MIZORUM, INDIA

Abstract

The pharmacokinetics of ceftriaxone was studied after intramuscular administration @ 20 mg/kg in adult Mizo local pig (zovawk). The drug concentration in plasma was quantified through High Performance Liquid Chromatography (HPLC) with UV detector. The maximum plasma concentrations (Cmax) of 25.92±1.05 µg.ml-1wasachieved at 0.5 h (Tmax), while the lowest plasma ceftriaxone concentration of 0.22±0.04 µg.ml-1wasobserved at 24 hfollowing intramuscular administration of ceftriaxone. It has been observed that plasma concentrations of ceftriaxone was maintained up to 24 h (1440 min) during the present investigation following IM administration of ceftriaxone @ 20 mg.kg-1 body weight. Pharmacokinetic profile and excellent bioavailability of ceftriaxone indicated that the drug can be used intramuscularly to treat susceptible bacterial infections in pig.

Keywords

• Ceftriaxone
• Pharmacokinetics
• Pig