Syndroma Stevens-Johnson - toxic epidermal necrolysis overlap associated with carbamazepine in patient with secondary epilepsy caused by brain tumor (Glioblastoma multiforme)

Abstract

Stevens-Johnson syndrome (SJS) is a severe, episodic, acute mucocutaneous reaction that is most often elicited by drugs and occasionally by infections. The drugs commonly implicated as the cause of SJS are anticonvulsants, sulfonamides, non-steroidal anti-inflammatory drugs and antibiotics. Carbamazepine has been commonly implicated in SJS. We report a case of SJS-TEN overlap syndrome developing in patient who was prescribed carbamazeine after epileptic attack during radiotherapy for the purpose of treatment Glioblastoma multiforme, patients underlying disease, whose symptomatology deteriorated patients condition.

Keywords

• Stevens-Johnson syndrome
• toxic epidermal necrolysis
• carbamazepine