Safety and antitumor activity of dostarlimab in patients with advanced or recurrent DNA mismatch repair deficient/microsatellite instability-high (dMMR/MSI-H) or proficient/stable (MMRp/MSS) endometrial cancer: interim results from GARNET—a phase I, single-arm study

• Lucy Gilbert,
• Ana Oaknin,
• Prafull Ghatage,
• Rebecca Kristeleit,
• Wei Guo,
• Sharad Ghamande,
• Valentina Boni,
• Jubilee Brown,
• Xinwei Han,
• Vanessa Samouëlian,
• Ellie Im,
• Renaud Sabatier,
• Anna V Tinker,
• David M O’malley,
• Bhavana Pothuri,
• Cara Mathews,
• Jennifer Veneris,
• Tao Duan,
• Linda Duska,
• Joshua Press,
• Charles Leath III,
• Sybil Zildjian

Affiliations

Lucy Gilbert

Department of Gynecologic Oncology, McGill University Health Centre Research Institute, Montreal, Quebec, Canada

Ana Oaknin

Gynaecologic Cancer Programme, Vall d`Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d’Hebron, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain

Prafull Ghatage

Department of Gynecological Oncology, University of Calgary, Calgary, Alberta, Canada

Rebecca Kristeleit

Department of Oncology, Guy’s and St Thomas’ Hospital NHS Foundation Trust, London, UK

Wei Guo

GlaxoSmithKline, Waltham, Massachusetts, USA

Sharad Ghamande

Georgia Cancer Center, Augusta University, Augusta, Georgia, USA

Valentina Boni

START Madrid-CIOCC, Centro Integral Oncológico Clara Campal, Hospital Universitario HM Sanchinarro, Madrid, Spain

Jubilee Brown

Division of Gynecologic Oncology, Levine Cancer Institute, Atrium Health, Charlotte, North Carolina, USA

Xinwei Han

GlaxoSmithKline, Waltham, Massachusetts, USA

Vanessa Samouëlian

Gynecologic Oncology Service, Department of Obstetrics and Gynecology, Université de Montréal, Montreal, Québec, Canada

Ellie Im

GlaxoSmithKline, Waltham, Massachusetts, USA

Renaud Sabatier

Department of Medical Oncology, Institut Paoli Calmettes, Aix-Marseille University, Marseille, France

Anna V Tinker

Department of Medicine, BC Cancer, Vancouver, British Columbia, Canada

David M O’malley

Department of Obstetrics and Gynecology, The Ohio State University James Comprehensive Cancer Center, Columbus, Ohio, USA

Bhavana Pothuri

Department of Obstetrics and Gynecology, NYU Langone Health, Perlmutter Cancer Center, New York University, New York, New York, USA

Cara Mathews

Department of Gynecological Oncology, Women and Infants Hospital of Rhode Island, Providence, Rhode Island, USA

Jennifer Veneris

GlaxoSmithKline, Waltham, Massachusetts, USA

Tao Duan

GlaxoSmithKline, Waltham, Massachusetts, USA

Linda Duska

Department of Gynecological Oncology, Emily Couric Clinical Cancer Center, University of Virginia, Charlottesville, Virginia, USA

Joshua Press

Gynecologic Oncology and Pelvic Surgery, Swedish Cancer Institute, Seattle, Washington State, USA

Charles Leath III

O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA

Sybil Zildjian

GlaxoSmithKline, Waltham, Massachusetts, USA