A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis

Qiyu Feng; Chengliang Zhang; David Lum; Joseph E. Druso; Bryant Blank; Kristin F. Wilson; Alana Welm; Marc A. Antonyak; Richard A. Cerione

doi:10.1038/ncomms14450

Nature Communications (Feb 2017)

A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis

Qiyu Feng,
Chengliang Zhang,
David Lum,
Joseph E. Druso,
Bryant Blank,
Kristin F. Wilson,
Alana Welm,
Marc A. Antonyak,
Richard A. Cerione

Affiliations

Qiyu Feng: Department of Molecular Medicine, Cornell University
Chengliang Zhang: Department of Molecular Medicine, Cornell University
David Lum: Huntsman Cancer Institute, University of Utah
Joseph E. Druso: Department of Molecular Medicine, Cornell University
Bryant Blank: Department of Biomedical Sciences, Cornell University
Kristin F. Wilson: Department of Molecular Medicine, Cornell University
Alana Welm: Huntsman Cancer Institute, University of Utah
Marc A. Antonyak: Department of Molecular Medicine, Cornell University
Richard A. Cerione: Department of Molecular Medicine, Cornell University

DOI: https://doi.org/10.1038/ncomms14450
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 17

Abstract

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Extracellular vesicles (EVs) contain VEGF and can contribute to tumour angiogenesis, although the mechanism remains unclear. Here, the authors find that a form of VEGF (VEGF90K) resistant to Bevacizumab but sensitive to HSP90 inhibitors, associates with EVs through its interaction with Hsp90.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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